Analysis Tools
immune system
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• reduced differentiation to T-helper 2 and 17 cells in vitro
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• reduced differentiation to effector T cells as determined by lower Tnfa, Ifng and Il2 production
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• reduced number of Foxp+ CD4+ T cells in spleen
• normal number of Foxp+ CD4+ T cells in thymus and mesenteric lymph nodes
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• reduced TH17 differentiation of naive CD4 T cells in vitro
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• reduced TH2 differentiation of naive CD4 T cells in vitro
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• reduced proliferative response after 36 h stimulation with anti-TCRbeta mAb plus anti-CD28 mAb in vitro
• reduced expansion of OVA-specific CD8+ T cells in spleen after OVA-peptide-expressing Listeria monocytogenes (Lm-OVA) infection
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• reduced effector T cell differentiation of CD8+ T cells
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• reduced number of invariant NKT cells in spleen
• normal number of invariant NKT cells in thymus and mesenteric lymph nod
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• reduced Il2 production in CD4+ T cells
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• no disease development, no body weight reduction, no CD3e+ T cell infiltration of spinal cord, reduced level of infiltrating cells, reduced demyelination in spinal cord after EAE induction
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• significant decrease in mononuclear cells infiltrating lung peribronchiolar regions after intranasal administration of OVA following immunization with OVA
• less mucus production and goblet cell neoplasia in bronchioles after intranasal administration of OVA following immunization with OVA
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hematopoietic system
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• normal thymic T cell development and spleen T cell number
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• reduced differentiation to T-helper 2 and 17 cells in vitro
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• reduced differentiation to effector T cells as determined by lower Tnfa, Ifng and Il2 production
|
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• reduced number of Foxp+ CD4+ T cells in spleen
• normal number of Foxp+ CD4+ T cells in thymus and mesenteric lymph nodes
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• reduced TH17 differentiation of naive CD4 T cells in vitro
|
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• reduced TH2 differentiation of naive CD4 T cells in vitro
|
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• reduced proliferative response after 36 h stimulation with anti-TCRbeta mAb plus anti-CD28 mAb in vitro
• reduced expansion of OVA-specific CD8+ T cells in spleen after OVA-peptide-expressing Listeria monocytogenes (Lm-OVA) infection
|
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• reduced effector T cell differentiation of CD8+ T cells
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• reduced number of invariant NKT cells in spleen
• normal number of invariant NKT cells in thymus and mesenteric lymph nod
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homeostasis/metabolism
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• lower basal oxygen consumption rate (OCR) and spare respiratory capacity (SRC) 24 h after TCR-stimulation in activated CD8+ T cells
• lower spare respiratory capacity (SRC) 24 h after TCR-stimulation in activated CD4+ T cells
• lower spare respiratory capacity (SRC) 8 h after TCR-stimulation in activated CD8+ T ce
• normal basal oxygen consumption rate (OCR) 24 h after TCR-stimulation in activated CD4+ T cells
• normal basal oxygen consumption rate (OCR) 8 h after TCR-stimulation in activated CD8+ T cells
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• lower extracellular acidification rate (ECAR) 24 h after TCR- stimulation in activated CD4+ and activated CD8+ T cells
• normal extracellular acidification rate (ECAR) 8 h after TCR- stimulation in activated CD8+ T cells
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• reduced intracellular tyrosine phosphorylation and ATP, lactate, NAD+ and NADH levels 24 h after TCR-stimulation in activated CD8+ T cells
• normal intracellular tyrosine phosphorylation and ATP, lactate, NAD+ and NADH levels 6 h after TCR-stimulation in activated CD8+ T cells
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• reduced intracellular IMP, AMP, GMP and UMP levels 24 h after TCR-stimulation in activated CD8+ T cells
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