Phenotypes associated with this allele

• Allele Symbol: Vwf^tm1.1Vhf
• Allele Name: targeted mutation 1.1, Veronica H Flood
• Allele ID: MGI:6473963
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vwf^tm1.1Vhf/Vwf^tm1.1Vhf	involves: C57BL/6J * C57BL/6N	MGI:6473965
ht2	Vwf^tm1.1Vhf/Vwf^+	involves: C57BL/6J * C57BL/6N	MGI:6473967

Genotype
MGI:6473965

hm1

• Allelic Composition: Vwf^tm1.1Vhf/Vwf^tm1.1Vhf
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

homeostasis/metabolism

abnormal blood coagulation ( J:295694 )

• occlusion time in the ferric chloride-induced injury model is slower than in wild-type mice

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

decreased susceptibility to induced thrombosis ( J:295694 )

• thrombosis induced by ferric chloride-induced injury is decreased

increased bleeding time ( J:295694 )

• homozygous mice bleed longer than heterozygous or wild-type mice and show increased blood loss in the tail clip bleeding model

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Willebrand's disease		DOID:12531		J:295694

Genotype
MGI:6473967

ht2

• Allelic Composition: Vwf^tm1.1Vhf/Vwf⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N

hematopoietic system

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

homeostasis/metabolism

abnormal blood coagulation ( J:295694 )

• occlusion time in the ferric chloride-induced injury model is slower than in wild-type mice

abnormal platelet physiology ( J:295694 )

• blood shows a decrease in platelet adhesion to type IV collagen under flow

• however, mice exhibit normal platelet aggregation induced by type I or type IV collagen under static conditions

decreased susceptibility to induced thrombosis ( J:295694 )

• thrombosis induced by ferric chloride-induced injury is decreased

increased bleeding time ( J:295694 )

• mice bleed longer than wild-type mice and show increased blood loss in the tail clip bleeding model

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
von Willebrand's disease		DOID:12531		J:295694