Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Ndufab1)#Xiwa
• Allele Name: transgene insertion, Xianhua Wang
• Allele ID: MGI:6476770
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Ndufab1)#Xiwa/0	involves: C57BL/6J	MGI:6476949

Genotype
MGI:6476949

tg1

• Allelic Composition: Tg(CAG-Ndufab1)#Xiwa/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:293657 )

N • normal respiratory quotient (exchange ratio) after 13 weeks on HFD

decreased circulating glucose level ( J:293657 )

• reduced fed blood glucose level increase when fed HFD

decreased fasting circulating glucose level ( J:293657 )

• when fed HFD or regular chow

increased energy expenditure ( J:293657 )

• in both dark and light phase when fed HFD

decreased susceptibility to diet-induced obesity ( J:293657 )

• delayed start of weight gain and reduced weight gain after 13 weeks on high-fat diet (HFD)

• lower fat mass percentage and higher lean mass percentage after 13 weeks on HFD

• reduced blood cholesterol level increase after 13 weeks on HFD

• normal blood triglyceride level increase after 13 weeks on HFD

increased carbon dioxide production ( J:293657 )

• in both dark and light phase when fed HFD

increased oxygen consumption ( J:293657 )

• in both dark and light phase when fed HFD

improved glucose tolerance ( J:293657 )

• reduced fasting and fed blood glucose level increase when fed HFD and reduced fasting blood glucose level increase when fed regular chow

increased insulin sensitivity ( J:293657 )

• when fed HFD, with or without glucose stimulation

adipose tissue

decreased brown fat cell lipid droplet size ( J:293657 )

• after 13 weeks on HFD

decreased brown fat cell size ( J:293657 )

• visceral adipocytes after 13 weeks on HFD

cellular

cellular phenotype ( J:293657 )

N • normal mitochondrial cristae in skeletal muscle

abnormal redox activity ( J:293657 )

• in skeletal muscle (flexor digitorum brevis (FDB) cells)

growth/size/body

decreased susceptibility to diet-induced obesity ( J:293657 )

• delayed start of weight gain and reduced weight gain after 13 weeks on high-fat diet (HFD)

• lower fat mass percentage and higher lean mass percentage after 13 weeks on HFD

• reduced blood cholesterol level increase after 13 weeks on HFD

• normal blood triglyceride level increase after 13 weeks on HFD

behavior/neurological

behavior/neurological phenotype ( J:293657 )

N • normal food intake

hyperactivity ( J:293657 )

• increased home-cage activity when fed HFD