Phenotypes associated with this allele

• Allele Symbol: Alk^{tm1.1(ALK*F1174L)Heno}
• Allele Name: targeted mutation 1.1, Hideki Enomoto
• Allele ID: MGI:6476969
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alk^tm1.1(ALK*F1174L)Heno/Alk^tm1.1(ALK*F1174L)Heno	involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	MGI:6476975
cn2	Alk^tm1.1(ALK*F1174L)Heno/Alk^tm1.1(ALK*F1174L)Heno Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0	involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:6476981
cn3	Alk^tm1.1(ALK*F1174L)Heno/Alk^+ Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0	involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:6476983
cn4	Alk^tm1.1(ALK*F1174L)Heno/Alk^tm1.1(ALK*F1174L)Heno Tmem163^Tg(ACTB-cre)2Mrt/Tmem163^+	involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL	MGI:6476978
cn5	Alk^tm1.1(ALK*F1174L)Heno/Alk^tm1.1(ALK*F1174L)Heno Tg(Mpz-cre)94Imeg/0	involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	MGI:6476976

Genotype
MGI:6476975

hm1

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk^{tm1.1(ALK*F1174L)Heno}
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:294092 )

• mice show normal appearance and fertility

Genotype
MGI:6476981

cn2

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk^{tm1.1(ALK*F1174L)Heno}; Tg(Mpz-cre)94Imeg/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL

mortality/aging

premature death ( J:294092 )

• mice show enhanced lethality compared to single Tg(Th-MYCN)41Waw expressing mice

neoplasm

increased neuroblastoma incidence ( J:294092 )

• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice

decreased tumor latency ( J:294092 )

• mice show earlier onset of neuroblastoma than in single Tg(Th-MYCN)41Waw expressing mice

nervous system

increased neuroblastoma incidence ( J:294092 )

• mice develop neuroblastoma with earlier onset, higher penetrance and enhanced lethality than in single Tg(Th-MYCN)41Waw expressing mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:294092

Genotype
MGI:6476983

cn3

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk⁺; Tg(Mpz-cre)94Imeg/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL

mortality/aging

decreased tumor-free survival time ( J:294092 )

• mice that develop thoracic and/or abdominal tumors die by 6 months

neoplasm

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

nervous system

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:294092

Genotype
MGI:6476978

cn4

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk^{tm1.1(ALK*F1174L)Heno}; Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL

nervous system

abnormal stellate ganglion morphology ( J:294092 )

• size of the sympathetic ganglia (stellate ganglia) is larger at E13.5

neoplasm

neoplasm ( J:294092 )

N • mice show no overt signs of tumorigenesis

Genotype
MGI:6476976

cn5

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk^{tm1.1(ALK*F1174L)Heno}; Tg(Mpz-cre)94Imeg/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL

nervous system

abnormal sympathetic ganglion morphology ( J:294092 )

• increase in proliferation of sympathetic ganglion progenitors

enlarged superior cervical ganglion ( J:294092 )

• size of the sympathetic ganglia (superior cervical ganglia) is larger at E13.5

• increase in cell numbers in superior cervical ganglia

neoplasm

neoplasm ( J:294092 )

N • mice show no overt signs of tumorigenesis