About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp422em1Mode
endonuclease-mediated mutation 1, Delin Mo
MGI:6477290
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zfp422em1Mode/Zfp422em1Mode
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S4/SvJaeSor * C57BL/6J MGI:6477291
cn2
 		Zfp422em1Mode/Zfp422em1Mode
Pax7tm1(cre/ERT2)Gaka/Pax7+ 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl MGI:6477293


Genotype
MGI:6477291
cn1
Allelic
Composition		 Zfp422em1Mode/Zfp422em1Mode
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Zfp422em1Mode mutation (0 available); any Zfp422 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:297035 )
• decreased weight at E17

muscle
abnormal myoblast differentiation ( J:297035 )
• differentiation of isolated myoblasts is impaired with both the differentiation and fusion indices decreased compared to controls
abnormal skeletal muscle fiber morphology ( J:297035 )
• the shape of the dorsal muscles is not well organized compared to controls at E17
decreased skeletal muscle fiber size ( J:297035 )
• smaller dorsal muscle myofibers at E17

cellular
abnormal myoblast differentiation ( J:297035 )
• differentiation of isolated myoblasts is impaired with both the differentiation and fusion indices decreased compared to controls




Genotype
MGI:6477293
cn2
Allelic
Composition		 Zfp422em1Mode/Zfp422em1Mode
Pax7tm1(cre/ERT2)Gaka/Pax7+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1(cre/ERT2)Gaka mutation (1 available); any Pax7 mutation (38 available)
Zfp422em1Mode mutation (0 available); any Zfp422 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myoblast differentiation ( J:297035 )
• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation
• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices
impaired skeletal muscle regeneration ( J:297035 )
• following CTX-induced muscle injury muscles in tamoxifen treated mice show smaller regenerated myofiber cross-section area

cellular
abnormal myoblast differentiation ( J:297035 )
• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation
• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory