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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp422em1Mode
endonuclease-mediated mutation 1, Delin Mo
MGI:6477290
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zfp422em1Mode/Zfp422em1Mode
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S4/SvJaeSor * C57BL/6J MGI:6477291
cn2
 		Zfp422em1Mode/Zfp422em1Mode
Pax7tm1(cre/ERT2)Gaka/Pax7+ 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl MGI:6477293


Genotype
MGI:6477291
cn1
Allelic
Composition		 Zfp422em1Mode/Zfp422em1Mode
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
Zfp422em1Mode mutation (0 available); any Zfp422 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:297035 )
• decreased weight at E17

muscle
abnormal myoblast differentiation ( J:297035 )
• differentiation of isolated myoblasts is impaired with both the differentiation and fusion indices decreased compared to controls
abnormal skeletal muscle fiber morphology ( J:297035 )
• the shape of the dorsal muscles is not well organized compared to controls at E17
decreased skeletal muscle fiber size ( J:297035 )
• smaller dorsal muscle myofibers at E17

cellular
abnormal myoblast differentiation ( J:297035 )
• differentiation of isolated myoblasts is impaired with both the differentiation and fusion indices decreased compared to controls




Genotype
MGI:6477293
cn2
Allelic
Composition		 Zfp422em1Mode/Zfp422em1Mode
Pax7tm1(cre/ERT2)Gaka/Pax7+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1(cre/ERT2)Gaka mutation (1 available); any Pax7 mutation (38 available)
Zfp422em1Mode mutation (0 available); any Zfp422 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myoblast differentiation ( J:297035 )
• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation
• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices
impaired skeletal muscle regeneration ( J:297035 )
• following CTX-induced muscle injury muscles in tamoxifen treated mice show smaller regenerated myofiber cross-section area

cellular
abnormal myoblast differentiation ( J:297035 )
• decrease in the number of myogenin positive cells in cultured satellite cells from tamoxifen treated mice indicating a defect in myoblast differentiation
• when induced to differentiate for 3 days satellite cells for fewer myotubes and have reduced fusion and differentiation indices




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory