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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp63tm3.2Aam
targeted mutation 3.2, Alea A Mills
MGI:6477385
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp63tm3.2Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477399
ht2
 		Trp63tm3.2Aam/Trp63+ involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477402
ht3
 		Trp63tm2.1Aam/Trp63tm3.2Aam involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:6477410


Genotype
MGI:6477399
hm1
Allelic
Composition		 Trp63tm3.2Aam/Trp63tm3.2Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
abnormal embryo development ( J:294158 )
• defects in epithelial morphogenesis

integument
abnormal skin development ( J:294158 )
• neonates lack a mature skin barrier

limbs/digits/tail
abnormal limb morphology ( J:294158 )
• neonates exhibit severe limb defects including limb truncations
short limbs ( J:294158 )
• limb truncations




Genotype
MGI:6477402
ht2
Allelic
Composition		 Trp63tm3.2Aam/Trp63+
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:294158 )
• approximate 8% lethality in weanlings, affecting only males

craniofacial
craniofacial phenotype ( J:294158 )
N
• cleft palate is not detected in neonates




Genotype
MGI:6477410
ht3
Allelic
Composition		 Trp63tm2.1Aam/Trp63tm3.2Aam
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm2.1Aam mutation (0 available); any Trp63 mutation (60 available)
Trp63tm3.2Aam mutation (0 available); any Trp63 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

digestive/alimentary system
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

growth/size/body
cleft palate ( J:294158 )
• 100% of neonates exhibit cleft palate

integument
thick epidermis ( J:294158 )
• neonates exhibit an increase in epidermal thickness

limbs/digits/tail
limbs/digits/tail phenotype ( J:294158 )
N
• neonates do not exhibit limb defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory