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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tspo2em1Muti
endonuclease-mediated mutation 1, Mutsumi Inaba
MGI:6478279
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tspo2em1Muti/Tspo2em1Muti C57BL/6-Tspo2em1Muti MGI:6478298
ht2
 		Tspo2em1Muti/Tspo2+ C57BL/6-Tspo2em1Muti MGI:6478300


Genotype
MGI:6478298
hm1
Allelic
Composition		 Tspo2em1Muti/Tspo2em1Muti
Genetic
Background		 C57BL/6-Tspo2em1Muti
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tspo2em1Muti mutation (0 available); any Tspo2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:292525 )
N
• normal mean corpuscular volume and the mean corpuscular hemoglobin
abnormal erythroblast morphology ( J:292525 )
• increased number of binucleated (mostly polychromatic and orthochromatic) erythroblasts
• higher relative abundance of polychromatic and orthochromatic erythroblasts
• increased size of pyrenocytes
decreased hematocrit ( J:292525 )
• at age 6-8 and 20 weeks
decreased hemoglobin content ( J:292525 )
• reduced hemoglobin concentration at age 20 weeks
reticulocytosis ( J:292525 )
• increased reticulocyte count at age 6-8 and 20 weeks
increased erythrocyte sodium:potassium-exchanging ATPase activity ( J:292525 )
• higher Na:K-ATPase contents in RBC membranes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:292525 )
N
• normal total cholesterol levels
increased erythrocyte sodium:potassium-exchanging ATPase activity ( J:292525 )
• higher Na:K-ATPase contents in RBC membranes




Genotype
MGI:6478300
ht2
Allelic
Composition		 Tspo2em1Muti/Tspo2+
Genetic
Background		 C57BL/6-Tspo2em1Muti
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tspo2em1Muti mutation (0 available); any Tspo2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:292525 )
N
• normal mean corpuscular volume and the mean corpuscular hemoglobin
abnormal erythroblast morphology ( J:292525 )
• increased number of binucleated (mostly polychromatic and orthochromatic) erythroblasts

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:292525 )
N
• normal total cholesterol levels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory