Phenotypes associated with this allele

• Allele Symbol: Mideas^em1Shmc
• Allele Name: endonuclease-mediated mutation 1, Shaun M Cowley
• Allele ID: MGI:6479049
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mideas^em1Shmc/Mideas^em1Shmc	C57BL/6J-Mideas^em1Shmc	MGI:6479056

Genotype
MGI:6479056

hm1

• Allelic Composition: Mideas^em1Shmc/Mideas^em1Shmc
• Genetic Background: C57BL/6J-Mideas^em1Shmc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart shape ( J:291786 )

• malformed heart in E16.5 embryos

heart hypoplasia ( J:291786 )

• in E16.5 embryos

enlarged pericardium ( J:291786 )

• in E16.5 embryos

hematopoietic system

absent erythrocytes ( J:291786 )

• no red blood cells in heart and blood vessels in E16.5 embryos

• embryos found at E13.5, E14.5, E15.5 and E16.5 are pale

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:291786 )

• no pups born

• embryos found at E13.5, E14.5, E15.5 and E16.5 are pale and smaller than wild-type or heterozygotes

growth/size/body

fetal growth retardation ( J:291786 )

• embryos found at E13.5, E14.5, E15.5 and E16.5 are small

cellular

abnormal mitosis ( J:291786 )

• significant increase in chromosome misalignment during metaphase

immune system

immune system phenotype ( J:291786 )

N • normal spleen morphology in E16.5 embryos

N • normal haematopoietic cell content in E16.5 embryos

liver/biliary system

liver/biliary system phenotype ( J:291786 )

N • normal liver morphology in E16.5 embryos

N • normal haematopoietic cell content in E16.5 embryos