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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm2Thst
targeted mutation 2, Thorsten Stiewe
MGI:6479073
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Trp53tm2Thst/Trp53+ involves: 129S1/Sv * 129X1/SvJ MGI:6479114
ht2
Trp53tm2Thst/Trp53tm2.1Thst involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:6479115


Genotype
MGI:6479114
ht1
Allelic
Composition
Trp53tm2Thst/Trp53+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2Thst mutation (1 available); any Trp53 mutation (239 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 519 days




Genotype
MGI:6479115
ht2
Allelic
Composition
Trp53tm2Thst/Trp53tm2.1Thst
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm2.1Thst mutation (1 available); any Trp53 mutation (239 available)
Trp53tm2Thst mutation (1 available); any Trp53 mutation (239 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice develop tumors resulting in reduced survival (128 days)

neoplasm
• mice develop tumors resulting in reduced survival (128 days)
• however, tumor metastatic potential is normal

endocrine/exocrine glands

reproductive system

hematopoietic system

immune system





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory