All Phenotypes Trp53<tm2.1Thst> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp53^tm2.1Thst
targeted mutation 2.1, Thorsten Stiewe
MGI:6479078

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm2.1Thst/Trp53^tm2.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479119
ht2	Trp53^tm2.1Thst/Trp53⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479116
ht3	Trp53^tm2Thst/Trp53^tm2.1Thst	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:6479115
cx4	Trp53^tm2.1Thst/Trp53⁺ Tg(IghMyc)22Bri/0	involves: 129 * C57BL * SJL	MGI:6479118

Allelic Composition	Trp53^tm2.1Thst/Trp53^tm2.1Thst
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:282255 )

• mice develop tumors resulting in reduced survival (150 days)

neoplasm

abnormal tumor incidence ( J:282255 )

• mice develop tumors resulting in reduced survival (150 days)

• however, tumor metastatic potential is normal

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

increased B cell derived lymphoma incidence ( J:282255 )

• in some mice

increased carcinoma incidence ( J:282255 )

• in some mice

increased sarcoma incidence ( J:282255 )

• in some mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

reproductive system

increased testis tumor incidence ( J:282255 )

• in some mice

immune system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

hematopoietic system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

Allelic Composition	Trp53^tm2.1Thst/Trp53⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:282255 )

• median survival is 519 days

Allelic Composition	Trp53^tm2Thst/Trp53^tm2.1Thst
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (240 available)
Trp53^tm2Thst mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

neoplasm

abnormal tumor incidence ( J:282255 )

• mice develop tumors resulting in reduced survival (128 days)

• however, tumor metastatic potential is normal

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

increased B cell derived lymphoma incidence ( J:282255 )

• in some mice

increased carcinoma incidence ( J:282255 )

• in some mice

increased sarcoma incidence ( J:282255 )

• in some mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

increased testis tumor incidence ( J:282255 )

• in some mice

reproductive system

increased testis tumor incidence ( J:282255 )

• in some mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

immune system

increased T cell derived lymphoma incidence ( J:282255 )

• dominant tumor type

Allelic Composition	Trp53^tm2.1Thst/Trp53⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129 * C57BL * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Trp53^tm2.1Thst mutation (1 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:282255 )

• similar to mice with a null Trp53 allele, mice exhibit shorter survival than those with wild-type Trp53

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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