All Phenotypes Wdr45b<tm1c(EUCOMM)Hmgu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Nes-cre)1Kln/0 Wdr45b^{tm1c(EUCOMM)Hmgu}/Wdr45b^{tm1c(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:6480015
cn2	Tg(Nes-cre)1Kln/0 Wdr45b^{tm1c(EUCOMM)Hmgu}/Wdr45b^{tm1c(EUCOMM)Hmgu}	involves: C57BL/6 * SJL	MGI:6480012

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Nes-cre)1Kln/0 Wdr45b^{tm1c(EUCOMM)Hmgu}/Wdr45b^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Tg(Nes-cre)1Kln mutation (4 available)
Wdr45b^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Wdr45b mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:298097 )

• motor deficits at age 4 weeks

nervous system

Purkinje cell degeneration ( J:298097 )

• many dead cells at age 4 weeks

abnormal cerebellar granule cell morphology ( J:298097 )

• many dead cells at age 4 weeks

cerebellum atrophy ( J:298097 )

• severe cerebellar degeneration at age 4 weeks

• many dead Purkinje and granule cells at age 4 weeks

abnormal axon morphology ( J:298097 )

• dense fibrils and severely damaged myelinated nerve fibers in cerebellum at age 4 weeks

growth/size/body

postnatal growth retardation ( J:298097 )

• severe growth retardation of the few mice that are born

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:298097 )

• the few mice that are born die within 4 weeks

prenatal lethality, incomplete penetrance ( J:298097 )

• most embryos die

cellular

abnormal Golgi apparatus morphology ( J:298097 )

• accumulation of small fragmented and swollen rod-shaped Golgi membranes in cerebellar Purkinje cells at age 4 weeks

abnormal endoplasmic reticulum morphology ( J:298097 )

• highly enriched smooth ER membranes in cerebellar Purkinje cells and myelinated nerve fibers at age 4 weeks

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:298097 )

• severe reduction in cell number in first fissure of cerebellum at age 10 weeks

• neuronal damage in cerebral cortex

• increased Gfap protein expression in cerebral cortex and Iba1 protein expression in cerebellum

increased brain iron level ( J:298097 )

• iron depositions in cerebellar Purkinje and granule cells

Purkinje cell degeneration ( J:298097 )

• severe reduction in cell number in first fissure of cerebellum at age 10 weeks

decreased Purkinje cell number ( J:298097 )

• severe reduction in cell number in first fissure of cerebellum at age 10 weeks

cerebellum atrophy ( J:298097 )

• severe reduction in cell number in first fissure of cerebellum at age 10 weeks

• presence of dead cells, collapsed myelinated nerve fibers and lamellar bodies

abnormal axon morphology ( J:298097 )

• dense fibrils in cerebellar myelinated nerve fibers

cellular

cellular phenotype ( J:298097 )

N	• normal canonical autophagy in brain • normal endoplasmic reticulum morphology in cerebellar Purkinje cells at age 10 weeks

abnormal Golgi apparatus morphology ( J:298097 )

• accumulation of small fragmented and swollen rod-shaped Golgi membranes in cerebellar Purkinje cells at age 10 weeks

dilated mitochondrion ( J:298097 )

• swollen mitochondria in cerebellar Purkinje cells, myelinated nerve fibers, glomeruli and granule cells

behavior/neurological

limb grasping ( J:298097 )

• abnormal limb-clasping reflexes at age 10 weeks

impaired coordination ( J:298097 )

• lower latency to fall in rotarod test at age 10, 15 and 20 weeks

impaired limb coordination ( J:298097 )

• abnormal footprint assay patterns at age 10 weeks

homeostasis/metabolism

increased brain iron level ( J:298097 )

• iron depositions in cerebellar Purkinje and granule cells

growth/size/body

postnatal growth retardation ( J:298097 )

• from age 8 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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