Phenotypes associated with this allele

• Allele Symbol: Lnhrt^tm1.1Koho
• Allele Name: targeted mutation 1.1, Koh Ono
• Allele ID: MGI:6480016
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lnhrt^tm1.1Koho/Lnhrt^tm1.1Koho	involves: C57BL/6 * DBA/2	MGI:6487890

Genotype
MGI:6487890

hm1

• Allelic Composition: Lnhrt^tm1.1Koho/Lnhrt^tm1.1Koho
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:293789 )

N • normal heart weight to body weight (HW/BW) ratio 8 weeks after transverse aortic constriction (TAC)

N • normal blood pressure after transverse aortic constriction (TAC)

decreased myocardial fiber size ( J:293789 )

• reduced cardiomyocyte cross-sectional area after transverse aortic constriction (TAC)

thin interventricular septum ( J:293789 )

• 8 weeks after transverse aortic constriction (TAC)

decreased heart ventricle muscle contractility ( J:293789 )

• reduced ventricular ejection fraction volume at 5 and 8 weeks after transverse aortic constriction (TAC)

muscle

decreased myocardial fiber size ( J:293789 )

• reduced cardiomyocyte cross-sectional area after transverse aortic constriction (TAC)

decreased heart ventricle muscle contractility ( J:293789 )

• reduced ventricular ejection fraction volume at 5 and 8 weeks after transverse aortic constriction (TAC)

decreased susceptibility to induced muscular atrophy ( J:293789 )

• reduced cardiac fibrosis after transverse aortic constriction (TAC)