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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdpd2tm1.1Soc
targeted mutation 1.1, Shanthini Sockanathan
MGI:6487892
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gdpd2tm1.1Soc/Gdpd2tm1.1Soc involves: 129/Sv * BALB/cJ * C57BL/6J MGI:6487965
cx2
 		Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+ 		involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J MGI:6487970
ot3
 		Gdpd2tm1.1Soc/Y involves: 129/Sv * BALB/cJ * C57BL/6J MGI:6487966


Genotype
MGI:6487965
hm1
Allelic
Composition		 Gdpd2tm1.1Soc/Gdpd2tm1.1Soc
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine
abnormal spinal cord morphology ( J:291492 )
• ~20% increase in number of Pax7- Sox9+ and ~18% increase in Pax7- NFIA+ ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal number of Pax7+ Sox9+ and Pax7+ NFIA+ dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords

cellular
abnormal cell cycle ( J:291492 )
• shorter S phase and shorter cell-cycle length in ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal S phase and cell-cycle length in dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine

growth/size/body
growth/size/body region phenotype ( J:291492 )
N
• viable and no gross dysmorphology

reproductive system




Genotype
MGI:6487970
cx2
Allelic
Composition		 Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+
Genetic
Background		 involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
Hprt1tm1(CMV-GFP)Nat mutation (1 available); any Hprt1 mutation (1280 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6
increased oligodendrocyte number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes at age P14
• increased expression of myelin basic protein in KO allele expressing oligodendrocytes at age P14
• normal proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes and normal myelin basic protein expression at age P30

cellular
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6




Genotype
MGI:6487966
ot3
Allelic
Composition		 Gdpd2tm1.1Soc/Y
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine
abnormal spinal cord morphology ( J:291492 )
• ~20% increase in number of Pax7- Sox9+ and ~18% increase in Pax7- NFIA+ ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal number of Pax7+ Sox9+ and Pax7+ NFIA+ dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords

cellular
abnormal cell cycle ( J:291492 )
• shorter S phase and shorter cell-cycle length in ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal S phase and cell-cycle length in dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine

growth/size/body
growth/size/body region phenotype ( J:291492 )
N
• viable and no gross dysmorphology

reproductive system




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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory