About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdpd2tm1.1Soc
targeted mutation 1.1, Shanthini Sockanathan
MGI:6487892
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gdpd2tm1.1Soc/Gdpd2tm1.1Soc involves: 129/Sv * BALB/cJ * C57BL/6J MGI:6487965
cx2
 		Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+ 		involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J MGI:6487970
ot3
 		Gdpd2tm1.1Soc/Y involves: 129/Sv * BALB/cJ * C57BL/6J MGI:6487966


Genotype
MGI:6487965
hm1
Allelic
Composition		 Gdpd2tm1.1Soc/Gdpd2tm1.1Soc
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine
abnormal spinal cord morphology ( J:291492 )
• ~20% increase in number of Pax7- Sox9+ and ~18% increase in Pax7- NFIA+ ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal number of Pax7+ Sox9+ and Pax7+ NFIA+ dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords

cellular
abnormal cell cycle ( J:291492 )
• shorter S phase and shorter cell-cycle length in ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal S phase and cell-cycle length in dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine

growth/size/body
growth/size/body region phenotype ( J:291492 )
N
• viable and no gross dysmorphology

reproductive system




Genotype
MGI:6487970
cx2
Allelic
Composition		 Gdpd2tm1.1Soc/Gdpd2+
Hprt1tm1(CMV-GFP)Nat/Hprt1+
Genetic
Background		 involves: 129/Sv * 129P2 /SvPas * 129S * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
Hprt1tm1(CMV-GFP)Nat mutation (1 available); any Hprt1 mutation (1277 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6
increased oligodendrocyte number ( J:291492 )
• increased proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes at age P14
• increased expression of myelin basic protein in KO allele expressing oligodendrocytes at age P14
• normal proportion of cells containing KO allele among Olig2+ CC1+ differentiated oligodendrocytes and normal myelin basic protein expression at age P30

cellular
increased oligodendrocyte progenitor number ( J:291492 )
• increased proportion of cells containing KO allele among Ki67+ oligodendrocyte precursor cells (OPCs) at age P6
• increased proportion of cells containing KO allele among Olig2+ oligodendrocyte precursor cells (OPCs) in E14.5 embryos




Genotype
MGI:6487966
ot3
Allelic
Composition		 Gdpd2tm1.1Soc/Y
Genetic
Background		 involves: 129/Sv * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdpd2tm1.1Soc mutation (0 available); any Gdpd2 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine
abnormal spinal cord morphology ( J:291492 )
• ~20% increase in number of Pax7- Sox9+ and ~18% increase in Pax7- NFIA+ ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal number of Pax7+ Sox9+ and Pax7+ NFIA+ dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords

cellular
abnormal cell cycle ( J:291492 )
• shorter S phase and shorter cell-cycle length in ventral ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
• normal S phase and cell-cycle length in dorsal ventricular zone (VZ) progenitors in E12.5 embryo spinal cords
increased neuronal precursor proliferation ( J:291492 )
• higher proliferative activity of cultured oligodendrocyte precursor cells (OPCs) from neonatal spine

growth/size/body
growth/size/body region phenotype ( J:291492 )
N
• viable and no gross dysmorphology

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory