Analysis Tools
cardiovascular system
|
• on a high fat diet, obese mice fail to show an increase in systolic blood pressure compared to normal chow fed mutant controls, unlike wild-type mice where over 60% of obese mice showed an increase in blood pressure compared to normal diet wild-type controls
• on a normal chow diet, blood pressure is similar to wild-type controls
• weight gain on a high fat diet is similar to diet matched wild-type controls
|
|
• almost no force is developed by mesenteric artery segments following incubation with KC activator phorbol 12,13-dibutyrate unlike in wild-type control arteries
• show an inhibited tension force in both the initial and sustained phases following stimulation with 10uM norepinephrine
• while maximal forces induced by GPCR agonists are reduced the dose-response sensitivity is similar to controls
• contractile response to KCl is similar to wild-type controls
• high fat diet fails to induce an increase in mesenteric artery contractility in response to norepinephrine, phenylephrine, or U46619 unlike in diet matched wild-type controls
|
muscle
|
• almost no force is developed by mesenteric artery segments following incubation with KC activator phorbol 12,13-dibutyrate unlike in wild-type control arteries
• show an inhibited tension force in both the initial and sustained phases following stimulation with 10uM norepinephrine
• while maximal forces induced by GPCR agonists are reduced the dose-response sensitivity is similar to controls
• contractile response to KCl is similar to wild-type controls
• high fat diet fails to induce an increase in mesenteric artery contractility in response to norepinephrine, phenylephrine, or U46619 unlike in diet matched wild-type controls
|
