Phenotypes associated with this allele

• Allele Symbol: Stra8^em4Keish
• Allele Name: endonuclease-mediated mutation 4, Kei-ichiro Ishiguro
• Allele ID: MGI:6488119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stra8^em4Keish/Stra8^em4Keish	involves: 129S6/SvEvTac * C57BL/6J	MGI:6488171

Genotype
MGI:6488171

hm1

• Allelic Composition: Stra8^em4Keish/Stra8^em4Keish
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

azoospermia ( J:290712 )

♂ • absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks

abnormal male meiosis ( J:290712 )

♂ • premature entry into prometaphase of SYCP3+ spermatocyte-like cells (as early as age P10) as determined by histone H3Ser10 phosphorylation (H3S10P) on chromatin

♂ • absent meiosis I-specific kinetochore during premature metaphase entry of SYCP3+ spermatocyte-like cells

arrest of male meiosis ( J:290712 )

♂ • absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks

reproductive system

azoospermia ( J:290712 )

♂ • absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks

abnormal male meiosis ( J:290712 )

♂ • premature entry into prometaphase of SYCP3+ spermatocyte-like cells (as early as age P10) as determined by histone H3Ser10 phosphorylation (H3S10P) on chromatin

♂ • absent meiosis I-specific kinetochore during premature metaphase entry of SYCP3+ spermatocyte-like cells

arrest of male meiosis ( J:290712 )

♂ • absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks