Analysis Tools
reproductive system
azoospermia
(
J:290712
)
 |
• absence of post-meiotic spermatids and sperm in testes and epididymis at age 8 weeks
• absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks
|
 |
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• premature entry into mitotic prometaphase of SYCP3+ ovarian germ cells as determined by chromosome condensation and histone H3Ser10 phosphorylation (H3S10P) on chromatin
|
|
|
• premature entry into mitotic prometaphase of SYCP3+ spermatocyte-like cells (as early as age P10) as determined by chromosome condensation and histone H3Ser10 phosphorylation (H3S10P) on chromatin
• absent meiosis I-specific kinetochore during premature metaphase entry of SYCP3+ spermatocyte-like cells
• prophase I skipped in SYCP3+ spermatocyte-like cells prematurely entering metaphase
• SYCP3+ spermatocyte-like cells prematurely entering metaphase fail to undergo cell-cycle arrest and instead enter mitotic cell cycle, as determined by mitotic cyclin A2 (CCNA2) expression
|
|
|
• absence of post-meiotic spermatids and sperm in testes and epididymis at age 8 weeks
• absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks
|
|
|
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• patchy SYCP3 aggregates in ovarian germ cells and failure to undergo homolog synapsis in E13.5E17.5 embryos
|
|
|
• increased apoptosis of SYCP3+ spermatocyte-like cells prematurely entering mitosis
|
|
|
• at age 4 weeks
|
|
|
• at age 4 weeks
|
|
|
• at age 8 weeks
|
cellular
azoospermia
(
J:290712
)
|
|
• absence of post-meiotic spermatids and sperm in testes and epididymis at age 8 weeks
• absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks
|
|
|
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• premature entry into mitotic prometaphase of SYCP3+ ovarian germ cells as determined by chromosome condensation and histone H3Ser10 phosphorylation (H3S10P) on chromatin
|
|
|
• premature entry into mitotic prometaphase of SYCP3+ spermatocyte-like cells (as early as age P10) as determined by chromosome condensation and histone H3Ser10 phosphorylation (H3S10P) on chromatin
• absent meiosis I-specific kinetochore during premature metaphase entry of SYCP3+ spermatocyte-like cells
• prophase I skipped in SYCP3+ spermatocyte-like cells prematurely entering metaphase
• SYCP3+ spermatocyte-like cells prematurely entering metaphase fail to undergo cell-cycle arrest and instead enter mitotic cell cycle, as determined by mitotic cyclin A2 (CCNA2) expression
|
|
|
• absence of post-meiotic spermatids and sperm in testes and epididymis at age 8 weeks
• absence of post-preleptotene stage spermatocytes at ages P18 and 8 weeks
|
|
|
• failure to produce bivalent chromatid pairs with chiasmata in oocyte-like cells isolated from 4-week old ovaries after hormone injection
|
|
|
• patchy SYCP3 aggregates in ovarian germ cells and failure to undergo homolog synapsis in E13.5E17.5 embryos
|
|
|
• increased apoptosis of SYCP3+ spermatocyte-like cells prematurely entering mitosis
|
endocrine/exocrine glands
|
|
• at age 4 weeks
|
|
|
• at age 4 weeks
|
|
|
• at age 8 weeks
|
