All Phenotypes Drc7<tm1.1Osb> MGI Mouse

immotile sperm ( J:284740 )

• sperm that are seen are immotile

small testis ( J:284740 )

• slightly smaller than those of wild-type controls

abnormal spermatogenesis ( J:284740 )

• elongated spermatids are abnormally retained in stage IX seminiferous tubules

• when found arrangement of mitochondria and outer dense fibers are abnormal, and the inner 9+2 arrangement of microtubules are missing

abnormal sperm axoneme morphology ( J:284740 )

• abnormal localization or loss of mitochondria

short sperm flagellum ( J:284740 )

• flagella are rarely found and those that are seen show impaired elongation

oligozoospermia ( J:284740 )

• hardly any spermatozoa are seen in the epididymis

abnormal sperm head morphology ( J:284740 )

• abnormal head shapes are seen at stage XI

• abnormal contraction of the manchette in an abnormal location results in formation of club heads

abnormal spermatid morphology ( J:284740 )

• barely any elongated spermatids are found

abnormal manchette morphology ( J:284740 )

male infertility ( J:284740 )

• males housed with wild-type females form plugs but fail to sire pups

• pups can be sired by intracytoplasmic sperm injection

cellular phenotype ( J:284740 )

N	• no defects are seen in cilia in the brain or trachea