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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam28tm1.2Dica
targeted mutation 1.2, Didier Cataldo
MGI:6488446
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam28tm1.2Dica/Adam28tm1.2Dica CJRj.129-Adam28tm1.2Dica MGI:6488580
hm2
 		Adam28tm1.2Dica/Adam28tm1.2Dica B6JRj.129-Adam28tm1.2Dica MGI:6488563


Genotype
MGI:6488580
hm1
Allelic
Composition		 Adam28tm1.2Dica/Adam28tm1.2Dica
Genetic
Background		 CJRj.129-Adam28tm1.2Dica
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam28tm1.2Dica mutation (0 available); any Adam28 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:298188 )
• increased tumor density in lungs after injection of mammary 4T1 cells

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in lungs 14 days after injection of mammary 4T1 cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

immune system
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in lungs 14 days after injection of mammary 4T1 cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

reproductive system
reproductive system phenotype ( J:298188 )
N
• fertile and normal litter size

growth/size/body
growth/size/body region phenotype ( J:298188 )
N
• normal postnatal weight gain




Genotype
MGI:6488563
hm2
Allelic
Composition		 Adam28tm1.2Dica/Adam28tm1.2Dica
Genetic
Background		 B6JRj.129-Adam28tm1.2Dica
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam28tm1.2Dica mutation (0 available); any Adam28 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:298188 )
• increased tumor density in lungs after injection of LLC or B16K1 tumor cells
• normal tumor proliferation and apoptosis rates in lungs after injection of LLC tumor cells

mortality/aging
increased susceptibility to induced morbidity/mortality ( J:298188 )
• decreased survival owing to increased metastatic pulmonary colonization after injection of LLC tumor cells

hematopoietic system
abnormal lymphocyte morphology ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal pulmonary infiltration of CD4+ CD3+ T cells, Treg cells and B cells 21 days after injection of LLC tumor cells
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice
• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells
abnormal alpha-beta T cell morphology ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal pulmonary infiltration of CD4+ CD3+ T cells and Treg cells 21 days after injection of LLC tumor cells
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice
• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

immune system
abnormal lymphocyte morphology ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal pulmonary infiltration of CD4+ CD3+ T cells, Treg cells and B cells 21 days after injection of LLC tumor cells
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice
• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells
abnormal alpha-beta T cell morphology ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal pulmonary infiltration of CD4+ CD3+ T cells and Treg cells 21 days after injection of LLC tumor cells
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice
• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice
• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:298188 )
N
• normal thymocyte development, weight and morphology at age 8 weeks

reproductive system
reproductive system phenotype ( J:298188 )
N
• fertile and normal litter size

growth/size/body
growth/size/body region phenotype ( J:298188 )
N
• normal postnatal weight gain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory