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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aig1em1Sagh
endonuclease-mediated mutation 1, Alan Saghatelian
MGI:6488486
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aig1em1Sagh/Aig1em1Sagh involves: C57BL/6 MGI:6488502
cx2
 		Adtrpem1Sagh/Adtrpem1Sagh
Aig1em1Sagh/Aig1em1Sagh 		involves: C57BL/6 MGI:6488501


Genotype
MGI:6488502
hm1
Allelic
Composition		 Aig1em1Sagh/Aig1em1Sagh
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aig1em1Sagh mutation (0 available); any Aig1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:289837 )
N
• no significant changes in the abundance of any of the major lipid classes
• no change in glucose metabolism
abnormal lipid metabolism ( J:289837 )
• decrease in 9-palmitic acid hydroxy stearic acid hydrolysis in multiple tissues




Genotype
MGI:6488501
cx2
Allelic
Composition		 Adtrpem1Sagh/Adtrpem1Sagh
Aig1em1Sagh/Aig1em1Sagh
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adtrpem1Sagh mutation (0 available); any Adtrp mutation (22 available)
Aig1em1Sagh mutation (0 available); any Aig1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:289837 )
N
• no significant changes in the abundance of any of the major lipid classes
• no change in glucose metabolism
increased fatty acids level ( J:289837 )
• increase in 9-fatty acid esters of hydroxy fatty acids (9-FAHFAs) in brown and white adipose tissue
• increase in adipose tissue is similar to that seen in mice homozygous for Adtrpem1Sagh alone
• unlike single homozygous mice, 9-FAHFA levels are also increased in kidneys
abnormal lipid metabolism ( J:289837 )
• decrease in 9-palmitic acid hydroxy stearic acid hydrolysis in multiple tissues
• decrease is additive compared to single homozygous mice in the kidney and brown adipose tissue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory