Phenotypes associated with this allele

• Allele Symbol: Mettl5^em1Schne
• Allele Name: endonuclease-mediated mutation 1, Robert Schneider
• Allele ID: MGI:6488597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mettl5^em1Schne/Mettl5^em1Schne	involves: C57BL/6NCrl	MGI:6488598

Genotype
MGI:6488598

hm1

• Allelic Composition: Mettl5^em1Schne/Mettl5^em1Schne
• Genetic Background: involves: C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:289086 )

• subviable, at weaning only half the expected number of homozygous mice are found

reproductive system

abnormal spermatogonia morphology ( J:289086 )

♂ • increase in spermatogonial debris seen in the epididymis in about half of males

seminiferous tubule degeneration ( J:289086 )

♂ • at 16 weeks of age scattered degenerated seminiferous tubules are seen

male infertility ( J:289086 )

♂

craniofacial

abnormal craniofacial morphology ( J:289086 )

• craniofacial abnormalities are detected in about 50% of homozygous mice at 14 weeks of age

abnormal nasal bone morphology ( J:289086 )

• altered nasal bone development

vision/eye

abnormal vitreous body morphology ( J:289086 )

• abnormal retrolental tissue consisting of melanocytes and endothelial cells in the vitreous body at 16 weeks of age

• seen with greater prevalence in the right eye

growth/size/body

abnormal nasal bone morphology ( J:289086 )

• altered nasal bone development

decreased body weight ( J:289086 )

• at 5 to 15 weeks of age

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:289086 )

• thresholds are increased starting at 14 weeks of age

behavior/neurological

decreased vertical activity ( J:289086 )

• display fewer rearings in an open field assay at 8 weeks of age

decreased locomotor activity ( J:289086 )

• hypoactive and hypoexploratory in an open field assay at 8 weeks of age

skeleton

abnormal nasal bone morphology ( J:289086 )

• altered nasal bone development

delayed cranial suture closure ( J:289086 )

• incomplete fusion of the frontal bone suture

endocrine/exocrine glands

seminiferous tubule degeneration ( J:289086 )

♂ • at 16 weeks of age scattered degenerated seminiferous tubules are seen

cellular

abnormal spermatogonia morphology ( J:289086 )

♂ • increase in spermatogonial debris seen in the epididymis in about half of males

respiratory system

abnormal nasal bone morphology ( J:289086 )

• altered nasal bone development