All Phenotypes Ankmy2<tm1b(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ankmy2^{tm1b(EUCOMM)Hmgu}
targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
MGI:6488662

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N	MGI:6489567
cx2	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Ift88^tm1Bky/Ift88^tm1Bky	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:6489572
cx3	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Gli2^tm1Alj/Gli2^tm1Alj	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:6489571
cx4	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Smo^tm1Amc/Smo^tm1Amc	involves: 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:6489570

Allelic Composition	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankmy2^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Ankmy2 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

craniorachischisis ( J:297055 )

• neural fold still completely open at 1012 somite stage (E8.5)

• open brain regions and extensive rostral malformations

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:297055 )

• embryos are arrested at 1012 somite stage (E8.5) and dont turn

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

craniorachischisis ( J:297055 )

• neural fold still completely open at 1012 somite stage (E8.5)

• open brain regions and extensive rostral malformations

Allelic Composition	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Ift88^tm1Bky/Ift88^tm1Bky
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankmy2^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Ankmy2 mutation (31 available)
Ift88^tm1Bky mutation (1 available); any Ift88 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart looping ( J:297055 )

pericardial effusion ( J:297055 )

cellular

absent embryonic cilia ( J:297055 )

embryo

embryo phenotype ( J:297055 )

N	• normal neural tube closure at 14-16 somite stage

absent embryonic cilia ( J:297055 )

homeostasis/metabolism

pericardial effusion ( J:297055 )

mortality/aging

embryonic lethality prior to organogenesis ( J:297055 )

• embryos are arrested at stage E9.5

Allelic Composition	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Gli2^tm1Alj/Gli2^tm1Alj
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankmy2^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Ankmy2 mutation (31 available)
Gli2^tm1Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• limited ventralization of thoracic and lumbar level neural tube; extensive ventralization of cranial level neural tube

incomplete rostral neuropore closure ( J:297055 )

• open neural tube in hindbrain area at 26-28 somite stage (E9.5)

mortality/aging

embryonic lethality prior to organogenesis ( J:297055 )

• embryos are arrested at 26-28 somite stage (E9.5)

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• limited ventralization of thoracic and lumbar level neural tube; extensive ventralization of cranial level neural tube

incomplete rostral neuropore closure ( J:297055 )

• open neural tube in hindbrain area at 26-28 somite stage (E9.5)

exencephaly ( J:297055 )

• open neural tube in hindbrain area at 26-28 somite stage (E9.5)

Allelic Composition	Ankmy2^{tm1b(EUCOMM)Hmgu}/Ankmy2^{tm1b(EUCOMM)Hmgu} Smo^tm1Amc/Smo^tm1Amc
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankmy2^{tm1b(EUCOMM)Hmgu} mutation (0 available); any Ankmy2 mutation (31 available)
Smo^tm1Amc mutation (1 available); any Smo mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:297055 )

• embryos are arrested at 1012 somite stage (E8.5)

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:297055 )

• ventralized neural tube in E9.5 embryos (ventral cell types ectopically specified at expense of lateral and dorsal types) throughout rostrocaudal extent of spinal cord and hindbrain

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