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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fan1em1Mem
endonuclease-mediated mutation 1, Marcy E MacDonald
MGI:6489290
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fan1em1Mem/Fan1em1Mem C57BL/6J-Fan1em1Mem MGI:6489855
cx2
 		Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+
Mlh1tm1Rak/Mlh1tm1Rak 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489857
cx3
 		Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489856


Genotype
MGI:6489855
hm1
Allelic
Composition		 Fan1em1Mem/Fan1em1Mem
Genetic
Background		 C57BL/6J-Fan1em1Mem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em1Mem mutation (0 available); any Fan1 mutation (99 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell nucleus morphology ( J:298297 )
• karyomegaly in the kidney at 5 months
increased cellular sensitivity to alkylating agents ( J:298297 )
• in response to mitomycin C in embryonic fibroblasts




Genotype
MGI:6489857
cx2
Allelic
Composition		 Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+
Mlh1tm1Rak/Mlh1tm1Rak
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em1Mem mutation (0 available); any Fan1 mutation (99 available)
Htttm5Mem mutation (2 available); any Htt mutation (178 available)
Mlh1tm1Rak mutation (1 available); any Mlh1 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:298297 )
N
• Htt CAG repeat stability is normal




Genotype
MGI:6489856
cx3
Allelic
Composition		 Fan1em1Mem/Fan1em1Mem
Htttm5Mem/Htt+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1em1Mem mutation (0 available); any Fan1 mutation (99 available)
Htttm5Mem mutation (2 available); any Htt mutation (178 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:298297 )
• expansion of the Htt CAG triplet repeats in striatum and liver at 5 months of age
increased cellular sensitivity to alkylating agents ( J:298297 )
• in response to mitomycin C in embryonic fibroblasts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory