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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rrm2bem1Mem
endonuclease-mediated mutation 1, Marcy E MacDonald
MGI:6489292
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rrm2bem1Mem/Rrm2bem1Mem C57BL/6J-Rrm2bem1Mem MGI:6489867
cx2
 		Htttm5Mem/Htt+
Rrm2bem1Mem/Rrm2b+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489868


Genotype
MGI:6489867
hm1
Allelic
Composition		 Rrm2bem1Mem/Rrm2bem1Mem
Genetic
Background		 C57BL/6J-Rrm2bem1Mem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rrm2bem1Mem mutation (0 available); any Rrm2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:298297 )
• at 3 months of age

renal/urinary system
pale kidney ( J:298297 )
• at 2.5 months of age

growth/size/body
weight loss ( J:298297 )
• at 2.5 months of age




Genotype
MGI:6489868
cx2
Allelic
Composition		 Htttm5Mem/Htt+
Rrm2bem1Mem/Rrm2b+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm5Mem mutation (2 available); any Htt mutation (178 available)
Rrm2bem1Mem mutation (0 available); any Rrm2b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:298297 )
N
• Htt CAG repeat stability is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory