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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ubr5em1Mem
endonuclease-mediated mutation 1, Marcy E MacDonald
MGI:6489293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ubr5em1Mem/Ubr5em1Mem C57BL/6J-Ubr5em1Mem MGI:6489873
cx2
 		Htttm5Mem/Htt+
Ubr5em1Mem/Ubr5+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:6489874


Genotype
MGI:6489873
hm1
Allelic
Composition		 Ubr5em1Mem/Ubr5em1Mem
Genetic
Background		 C57BL/6J-Ubr5em1Mem
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ubr5em1Mem mutation (0 available); any Ubr5 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:298297 )
• fewer than expected mice are present at weaning




Genotype
MGI:6489874
cx2
Allelic
Composition		 Htttm5Mem/Htt+
Ubr5em1Mem/Ubr5+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm5Mem mutation (2 available); any Htt mutation (178 available)
Ubr5em1Mem mutation (0 available); any Ubr5 mutation (117 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:298297 )
• expansion of the Htt CAG triplet repeats in striatum and liver at 5 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory