Phenotypes associated with this allele

• Allele Symbol: Carns1^tm1.2Meck
• Allele Name: targeted mutation 1.2, Matthias Eckhardt
• Allele ID: MGI:6489595
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Carns1^tm1.2Meck/Carns1^tm1.2Meck	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL	MGI:6489598

Genotype
MGI:6489598

hm1

• Allelic Composition: Carns1^tm1.2Meck/Carns1^tm1.2Meck
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

decreased olfactory sensory neuron number ( J:298850 )

• age related decline in number of olfactory receptor neurons at age 24 months

• normal apoptosis rate at age 24 months

• normal level of proliferating precursor basal cells at age 24 months

• normal olfactory bulb size at age 24 months

• normal number of granule and mitral cells in mitral cell layer of olfactory bulb at age 24 months

taste/olfaction

decreased olfactory sensory neuron number ( J:298850 )

• age related decline in number of olfactory receptor neurons at age 24 months

• normal apoptosis rate at age 24 months

• normal level of proliferating precursor basal cells at age 24 months

• normal olfactory bulb size at age 24 months

• normal number of granule and mitral cells in mitral cell layer of olfactory bulb at age 24 months

impaired olfaction ( J:298850 )

• increased detection threshold in modified habituation-dishabituation test for some odors at age 18 or 24 months

• normal time to find buried cookie at ages 3 months and 18 months

• normal odor preference behavior at age 18 months

• normal behavior in standard habituation-dishabituation test at age 18 mont

nervous system

decreased olfactory sensory neuron number ( J:298850 )

• age related decline in number of olfactory receptor neurons at age 24 months

• normal apoptosis rate at age 24 months

• normal level of proliferating precursor basal cells at age 24 months

• normal olfactory bulb size at age 24 months

• normal number of granule and mitral cells in mitral cell layer of olfactory bulb at age 24 months

craniofacial

decreased olfactory sensory neuron number ( J:298850 )

• age related decline in number of olfactory receptor neurons at age 24 months

• normal apoptosis rate at age 24 months

• normal level of proliferating precursor basal cells at age 24 months

• normal olfactory bulb size at age 24 months

• normal number of granule and mitral cells in mitral cell layer of olfactory bulb at age 24 months

behavior/neurological

behavior/neurological phenotype ( J:298850 )

N • normal behavior

mortality/aging

mortality/aging ( J:298850 )

N • normal survival rate

muscle

muscle phenotype ( J:298850 )

N • normal excitation-contraction coupling in skeletal muscle (extensor digitorum longus (EDL) and soleus (SOL) muscles) at age 6-8 months

N • normal muscle fiber diameter and number and location of nuclei

N • normal age-related grip strength decline between ages 3 months and 18 months

N • normal muscle weight and length at age 6-8 months

growth/size/body

growth/size/body region phenotype ( J:298850 )

N • normal body weight

decreased olfactory sensory neuron number ( J:298850 )

• age related decline in number of olfactory receptor neurons at age 24 months

• normal apoptosis rate at age 24 months

• normal level of proliferating precursor basal cells at age 24 months

• normal olfactory bulb size at age 24 months

• normal number of granule and mitral cells in mitral cell layer of olfactory bulb at age 24 months