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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prdm9em2Kpgn
endonuclease-mediated mutation 2, Kenneth Paigen
MGI:6489980
Summary 3 genotypes


Genotype
MGI:6489988
hm1
Allelic
Composition		 Prdm9em2Kpgn/Prdm9em2Kpgn
Genetic
Background		 C57BL/6J-Prdm9em2Kpgn/Kpgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA methylation during gametogenesis ( J:299008 )
• Background Sensitivity: a 5-fold reduction in the number of Prdm9-dependent H3K4me3 peaks and a decrease in peak intensity is found in homozygous spermatocytes compared with wild-type C57BL/6J, but methyltransferase activity is not abolished as it is in null homozygotes, and only one quarter of the double stranded breaks are at Prdm9-dependent hotspotsverus 85% in C57BL/6J controls while three quarters of the double stranded breaks are found in Prdm9-independent sites versus approximately 4% in C57BL/6J controls

endocrine/exocrine glands

reproductive system
abnormal DNA methylation during gametogenesis ( J:299008 )
• Background Sensitivity: a 5-fold reduction in the number of Prdm9-dependent H3K4me3 peaks and a decrease in peak intensity is found in homozygous spermatocytes compared with wild-type C57BL/6J, but methyltransferase activity is not abolished as it is in null homozygotes, and only one quarter of the double stranded breaks are at Prdm9-dependent hotspotsverus 85% in C57BL/6J controls while three quarters of the double stranded breaks are found in Prdm9-independent sites versus approximately 4% in C57BL/6J controls
reduced female fertility ( J:299008 )
• although homozygous females are sub-fertile, they do reproduce




Genotype
MGI:6500995
hm2
Allelic
Composition		 Prdm9em2Kpgn/Prdm9em2Kpgn
Genetic
Background		 (C57BL/6J-Prdm9em2Kpgn/Kpgn x WSB/EiJ)F2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands

reproductive system




Genotype
MGI:6490002
ht3
Allelic
Composition		 Prdm9em2Kpgn/Prdm9+
Genetic
Background		 C57BL/6J-Prdm9em2Kpgn/Kpgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm9em2Kpgn mutation (1 available); any Prdm9 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased oocyte number ( J:299008 )
• heterozygotes have an intermediate phenotype with fewer than normal oocytes but more than those found in homozygotes

reproductive system
decreased oocyte number ( J:299008 )
• heterozygotes have an intermediate phenotype with fewer than normal oocytes but more than those found in homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory