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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbc1d24em4Tbf
endonuclease-mediated mutation 4, Thomas B Friedman
MGI:6490519
Summary 2 genotypes


Genotype
MGI:6490525
hm1
Allelic
Composition		 Tbc1d24em4Tbf/Tbc1d24em4Tbf
Genetic
Background		 C57BL/6J-Tbc1d24em4Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d24em4Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:299025 )
N
• mice exhibit hearing and auditory brainstem response thresholds at P30, P60, and P90 indistinguishable from controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT autosomal dominant nonsyndromic deafness 65 DOID:0110586 OMIM:616044
 J:299025




Genotype
MGI:6490586
cx2
Allelic
Composition		 Cdh23Ahl+/Cdh23Ahl+
Tbc1d24em4Tbf/Tbc1d24em4Tbf
Genetic
Background		 B6.Cg-Cdh23Ahl+ Tbc1d24em4Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23Ahl+ mutation (4 available); any Cdh23 mutation (283 available)
Tbc1d24em4Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:299025 )
N
• mice exhibit normal hearing, auditory brainstem response thresholds at P30, P60, and P90, wave 1 latencies and amplitudes, and distortion product otoacoustic emissions

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT autosomal dominant nonsyndromic deafness 65 DOID:0110586 OMIM:616044
 J:299025




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory