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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbc1d24em5Tbf
endonuclease-mediated mutation 5, Thomas B Friedman
MGI:6490521
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbc1d24em5Tbf/Tbc1d24em5Tbf C57BL/6J-Tbc1d24em5Tbf MGI:6490527
ht2
 		Tbc1d24em2Tbf/Tbc1d24em5Tbf C57BL/6J-Tbc1d24em2Tbf Tbc1d24em5Tbf MGI:6490529


Genotype
MGI:6490527
hm1
Allelic
Composition		 Tbc1d24em5Tbf/Tbc1d24em5Tbf
Genetic
Background		 C57BL/6J-Tbc1d24em5Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d24em5Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:299025 )
• mice die during embryonic development




Genotype
MGI:6490529
ht2
Allelic
Composition		 Tbc1d24em2Tbf/Tbc1d24em5Tbf
Genetic
Background		 C57BL/6J-Tbc1d24em2Tbf Tbc1d24em5Tbf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbc1d24em2Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
Tbc1d24em5Tbf mutation (0 available); any Tbc1d24 mutation (82 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:299025 )
• mice usually die between P15 and P20

behavior/neurological
seizures ( J:299025 )
• mice die around P20 due to seizures

nervous system
seizures ( J:299025 )
• mice die around P20 due to seizures

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:299025 )
N
• mice exhibit normal hearing at P17, showing normal auditory brain stem response




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory