Phenotypes associated with this allele

• Allele Symbol: Pole3^em3Tbo
• Allele Name: endonuclease-mediated mutation 3, Thomas Boehm
• Allele ID: MGI:6490635
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pole3^em3Tbo/Pole3^em3Tbo	FVB-Pole3^em3Tbo	MGI:6491465

Genotype
MGI:6491465

hm1

• Allelic Composition: Pole3^em3Tbo/Pole3^em3Tbo
• Genetic Background: FVB-Pole3^em3Tbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:298827 )

• faster progression through S phase in DN3, DN4, and DP T cells

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

immune system

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

small thymus ( J:298827 )

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

decreased lymphocyte cell number ( J:298827 )

• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

decreased double-positive T cell number ( J:298827 )

• 50-fold reduction in thymus

decreased B cell number ( J:298827 )

• reduction in number of B220+ cells in bone marrow

decreased immature B cell number ( J:298827 )

• in bone marrow

decreased pre-B cell number ( J:298827 )

• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow

decreased gamma-delta T cell number ( J:298827 )

• 2-fold reduction in thymus

small spleen ( J:298827 )

decreased splenocyte number ( J:298827 )

• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

endocrine/exocrine glands

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

small thymus ( J:298827 )

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

hematopoietic system

increased thymocyte apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

abnormal thymus apoptosis ( J:298827 )

• increased apoptosis in DN1, DN2 and DN3 thymocytes

small thymus ( J:298827 )

increased DN3 thymocyte number ( J:298827 )

• proportion of DN3 cells increased in thymus

decreased lymphocyte cell number ( J:298827 )

• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

decreased thymocyte number ( J:298827 )

• significant reduction

decreased DN4 thymocyte number ( J:298827 )

• proportion of DN4 cells decreased in thymus

decreased double-positive T cell number ( J:298827 )

• 50-fold reduction in thymus

decreased B cell number ( J:298827 )

• reduction in number of B220+ cells in bone marrow

decreased immature B cell number ( J:298827 )

• in bone marrow

decreased pre-B cell number ( J:298827 )

• 3-fold reduction of B220+ IgM- CD43- cells in bone marrow

decreased gamma-delta T cell number ( J:298827 )

• 2-fold reduction in thymus

small spleen ( J:298827 )

decreased splenocyte number ( J:298827 )

• reduction in number of CD4+, CD8+ and CD19+ cells in spleen

embryo

embryo phenotype ( J:298827 )

N • no gross developmental anomalies

mortality/aging

mortality/aging ( J:298827 )

N • viable; born at expected Mendelian ratios