mortality/aging
• Mendelian ratios of embryos are seen at E9.5 but only 3.6% at E15, indicating that mutants die between E9.5 and E15.5
|
growth/size/body
• E15.5 mutant is smaller
|
embryo
• E9.5 embryos have heartbeats but have yet to undergo turning
|
cardiovascular system
• E15.5 mutant shows right ventricular hypoplasia
|
craniofacial
• E15.5 mutant exhibits craniofacial dysmorphia
|
vision/eye
anophthalmia
(
J:297666
)
• E15.5 mutant is anophthalmic
|