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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-Mmachc,-GFP)1Poche
transgene insertion 1, Ross Poche
MGI:6491446
Summary 3 genotypes


Genotype
MGI:6491477
cx1
Allelic
Composition		 Mmachctm1.1(NCOM)Mfgc/Mmachctm1.1(NCOM)Mfgc
Tg(CAG-Mmachc,-GFP)1Poche/0
Genetic
Background		 C57BL/6-Mmachctm1.1(NCOM)Mfgc Tg(CAG-Mmachc,-GFP)1Poche
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmachctm1.1(NCOM)Mfgc mutation (1 available); any Mmachc mutation (32 available)
Tg(CAG-Mmachc,-GFP)1Poche mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:297666 )
• weanlings are on average 30% smaller than controls and remain so throughout adulthood

homeostasis/metabolism
increased circulating homocysteine level ( J:297666 )
• adults exhibit tremendously elevated levels of homocysteine in plasma
increased circulating methylmalonic acid level ( J:297666 )
• adults exhibit tremendously elevated levels of methylmalonic acid in plasma

craniofacial
craniofacial phenotype ( J:297666 )
N
• mice do not exhibit any gross craniofacial abnormalities

nervous system
nervous system phenotype ( J:297666 )
N
• mice do not exhibit any gross neurological abnormalities

vision/eye
vision/eye phenotype ( J:297666 )
N
• mice do not exhibit any gross ocular abnormalities




Genotype
MGI:7310236
cx2
Allelic
Composition		 Tg(CAG-Mmachc,-GFP)1Poche/0
Hcfc1em1Poche/Y
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcfc1em1Poche mutation (0 available); any Hcfc1 mutation (8 available)
Tg(CAG-Mmachc,-GFP)1Poche mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:317822 )
• mice exhibit partial lethality, with fewer (3.6%) than the expected (12.5%) numbers seen at weaning

craniofacial
abnormal craniofacial morphology ( J:317822 )
• the craniofacial dysmorphia seen in Hcfc1em1Poche/Y mice, especially for the more severely affected frontal and nasal bone surface area and width, are not improved

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:317822 )
N
• mice exhibit normal plasma methylmalonic acid and homocysteine levels, indicating rescue of the inborn error of cobalamin metabolism




Genotype
MGI:6491475
tg3
Allelic
Composition		 Tg(CAG-Mmachc,-GFP)1Poche/0
Genetic
Background		 C57BL/6J-Tg(CAG-Mmachc,-GFP)1Poche
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:297666 )
• mice are viable, fertile and do not exhibit any overt phenotype




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory