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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mettl3tm1.1Jhha
targeted mutation 1.1, Jacob Hanna
MGI:6491677
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0 		involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6 MGI:6491904
cn2
 		Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Zp3-cre)93Knw/0 		involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * C57BL/6J MGI:6491906
cn3
 		Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Ddx4-cre)1Dcas/0 		involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB MGI:6491898
cn4
 		Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Stra8-icre)1Reb/0 		involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/NJ MGI:6491901


Genotype
MGI:6491904
cn1
Allelic
Composition		 Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Prm-cre)58Og/0
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation (0 available); any Mettl3 mutation (42 available)
Tg(Prm-cre)58Og mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:299108 )
N
• normal male fertility and seminiferous tubules morphology




Genotype
MGI:6491906
cn2
Allelic
Composition		 Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation (0 available); any Mettl3 mutation (42 available)
Tg(Zp3-cre)93Knw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal oocyte morphology ( J:299108 )
• all oocytes stalled at germinal vesicle stage; do not develop to two-cell stage upon fertilization
abnormal female meiosis ( J:299108 )
• all oocytes stalled at germinal vesicle stage; do not develop to two-cell stage upon fertilization

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:299108 )
N
• normal ovary morphology

reproductive system
abnormal oocyte morphology ( J:299108 )
• all oocytes stalled at germinal vesicle stage; do not develop to two-cell stage upon fertilization
abnormal female meiosis ( J:299108 )
• all oocytes stalled at germinal vesicle stage; do not develop to two-cell stage upon fertilization




Genotype
MGI:6491898
cn3
Allelic
Composition		 Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Ddx4-cre)1Dcas/0
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation (0 available); any Mettl3 mutation (42 available)
Tg(Ddx4-cre)1Dcas mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
small testis ( J:299108 )
• massive reduction in testis volume
testis degeneration ( J:299108 )
• severe degeneration

reproductive system
small testis ( J:299108 )
• massive reduction in testis volume
testis degeneration ( J:299108 )
• severe degeneration




Genotype
MGI:6491901
cn4
Allelic
Composition		 Mettl3tm1.1Jhha/Mettl3tm1.1Jhha
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettl3tm1.1Jhha mutation (0 available); any Mettl3 mutation (42 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
oligozoospermia ( J:299108 )
• 75% reduction in sperm count in cauda epididymis

endocrine/exocrine glands
seminiferous tubule degeneration ( J:299108 )
• mild degeneration
small testis ( J:299108 )
• significant reduction in testis volume

reproductive system
oligozoospermia ( J:299108 )
• 75% reduction in sperm count in cauda epididymis
seminiferous tubule degeneration ( J:299108 )
• mild degeneration
small testis ( J:299108 )
• significant reduction in testis volume
reduced male fertility ( J:299108 )
• 75% reduction in sperm count in cauda epididymis




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory