Analysis Tools
immune system
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• germinal center B cells have a reduced proliferation rate in immunized mice
• germinal center B cells have fewer cells at S phase compared with wild-type controls
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• neonatal transitional B cell development into neonatal CD5+ B1a cells is impeded
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• mice show mildly decreased cell populations at the T1 and T3 stages but increased T2 stage cells, indicating a defect at the transitional B cell stage
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• mice show mildly decreased populations at the T3 stage
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• mice show increased T2 stage cell populations
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• SRBC-immunized mice show less plasma cell differentiation in the bone marrow
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• B1 B cells, especially B1a cells, are ablated in the peritoneal cavity
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• in peritoneal cavity
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• slight increase in follicular B cells
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• precursor B cell (pre-B cell) population is slightly decreased in the bone marrow
• however, the immature and transitional B cell populations in the bone marrow and transitional B cell population in the peripheral blood are unchanged
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• the dark zone compartment is reduced in germinal centers accompanied by an increase in portion of light zone B cells
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• after immunization with the model antigen sheep red blood cells (SRBC), the percentage and the absolute number of germinal center B cells in the spleen, in the mesenteric lymph node and Peyers patch are reduced
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• mice do not generate IgG antibody responses against NP-LPS and NP-Ficoll
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• mice do not generate IgM antibody responses against NP-LPS and NP-Ficoll
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• mice exhibit a defect in T1 humoral immunity
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hematopoietic system
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• germinal center B cells have a reduced proliferation rate in immunized mice
• germinal center B cells have fewer cells at S phase compared with wild-type controls
|
|
• neonatal transitional B cell development into neonatal CD5+ B1a cells is impeded
|
|
• mice show mildly decreased cell populations at the T1 and T3 stages but increased T2 stage cells, indicating a defect at the transitional B cell stage
|
|
• mice show mildly decreased populations at the T3 stage
|
|
• mice show increased T2 stage cell populations
|
|
• SRBC-immunized mice show less plasma cell differentiation in the bone marrow
|
|
• B1 B cells, especially B1a cells, are ablated in the peritoneal cavity
|
|
• in peritoneal cavity
|
|
• slight increase in follicular B cells
|
|
• precursor B cell (pre-B cell) population is slightly decreased in the bone marrow
• however, the immature and transitional B cell populations in the bone marrow and transitional B cell population in the peripheral blood are unchanged
|
|
• the dark zone compartment is reduced in germinal centers accompanied by an increase in portion of light zone B cells
|
|
• after immunization with the model antigen sheep red blood cells (SRBC), the percentage and the absolute number of germinal center B cells in the spleen, in the mesenteric lymph node and Peyers patch are reduced
|
|
• mice do not generate IgG antibody responses against NP-LPS and NP-Ficoll
|
|
• mice do not generate IgM antibody responses against NP-LPS and NP-Ficoll
|
cellular
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• germinal center B cells have a reduced proliferation rate in immunized mice
• germinal center B cells have fewer cells at S phase compared with wild-type controls
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