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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card11em2Welu
endonuclease-mediated mutation 2, Wei Lu
MGI:6491989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card11em2Welu/Card11em2Welu involves: C57BL/6 MGI:6491995
ht2
 		Card11em2Welu/Card11+ involves: C57BL/6 MGI:6491996


Genotype
MGI:6491995
hm1
Allelic
Composition		 Card11em2Welu/Card11em2Welu
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11em2Welu mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged spleen ( J:292926 )

immune system
increased B cell proliferation ( J:292926 )
• germinal center B cells have an accelerated proliferation rate in immunized mice
• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation
increased transitional stage T2 B cell number ( J:292926 )
• a slight decrease in T2 stage B cell percentage during development
abnormal plasma cell differentiation ( J:292926 )
• SRBC-immunized mice show increased plasma cell differentiation in the bone marrow
increased germinal center B cell number ( J:292926 )
• after immunization with the model antigen sheep red blood cells (SRBC), the number of germinal center B cells are increased sightly
decreased mature B cell number ( J:292926 )
• mice exhibit less mature B cells in the bone marrow
increased B-1a cell number ( J:292926 )
• increased in the peritoneal cavity
increased B-1b cell number ( J:292926 )
• increased in the peritoneal cavity
increased marginal zone B cell number ( J:292926 )
• although the percentage of marginal zone B cells in the spleen is similar to wild-type mice, the absolute number of marginal zone B cell numbers is twice as high as that of wild-type
increased pre-B cell number ( J:292926 )
• mice exhibit more pre-B cells in the bone marrow

hematopoietic system
increased B cell proliferation ( J:292926 )
• germinal center B cells have an accelerated proliferation rate in immunized mice
• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation
increased transitional stage T2 B cell number ( J:292926 )
• a slight decrease in T2 stage B cell percentage during development
abnormal plasma cell differentiation ( J:292926 )
• SRBC-immunized mice show increased plasma cell differentiation in the bone marrow
increased germinal center B cell number ( J:292926 )
• after immunization with the model antigen sheep red blood cells (SRBC), the number of germinal center B cells are increased sightly
decreased mature B cell number ( J:292926 )
• mice exhibit less mature B cells in the bone marrow
increased B-1a cell number ( J:292926 )
• increased in the peritoneal cavity
increased B-1b cell number ( J:292926 )
• increased in the peritoneal cavity
increased marginal zone B cell number ( J:292926 )
• although the percentage of marginal zone B cells in the spleen is similar to wild-type mice, the absolute number of marginal zone B cell numbers is twice as high as that of wild-type
increased pre-B cell number ( J:292926 )
• mice exhibit more pre-B cells in the bone marrow

cellular
increased B cell proliferation ( J:292926 )
• germinal center B cells have an accelerated proliferation rate in immunized mice
• germinal center B cells have more cells at S phase compared with wild-type controls, indicating promotion of entry into S phase and proliferation




Genotype
MGI:6491996
ht2
Allelic
Composition		 Card11em2Welu/Card11+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11em2Welu mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B-1 B cell number ( J:292926 )
• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants
increased marginal zone B cell number ( J:292926 )
• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants

hematopoietic system
increased B-1 B cell number ( J:292926 )
• B1 B cell development is intermediately enhanced compared with wild-type and homozygous mutants
increased marginal zone B cell number ( J:292926 )
• marginal zone B cell development is intermediately enhanced compared with wild-type and homozygous mutants




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11/12/2024
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