Analysis Tools
mortality/aging
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• mice die of dehydration if not fed with wet chow from P17 to P32
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growth/size/body
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• mice are smaller in size around weaning but catch up in size at the 5th week
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behavior/neurological
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• mice show reduced alternation in arm entry in the Y-maze, indicating impaired spatial working memory
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• mice follow littermates excessively, resulting in fighting and injuries, indicating inappropriate juvenile aggressive behavior
• however, no aggressive behavior in the one-chamber test is seen
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• mice show elevated anxiety, with fewer entries to the center zone and less time spent in the center zone in the open field and spending more time in closed arms are fewer entries in open arms in the elevated-plus maze
• CDPPB injection ameliorates the anxiety-like behavior
• however, mice show a mild defect in sucrose consumption only on the first day of habituation but not the remaining 5 days, suggesting no anhedonia and show normal behavior in the forced swim test indicating no evidence of depression and exhibit normal locomotion in the open field test at 8-10 weeks of age
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• more mice drop off the hanging wire before the cut-off time than wild-type mice
• however, 8-10 week old mice exhibit normal motor strength in the hanging wire test
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• mice spend more time in sniffing the stranger mouse both in the one-chamber test and the three-chamber test
• 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) injection reduces the hyper-sociability
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homeostasis/metabolism
dehydration
(
J:293568
)
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• mice die of dehydration if not fed with wet chow from P17 to P32
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nervous system
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• pyramidal neuron neurite morphogenesis is impaired
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• pyramidal neurons from the CA1 region of the hippocampus exhibit elongated dendritic spines
• pyramidal neurons show reduced dendritic complexity, with reduced length and branching starting at the third order for basal dendrites and at the seventh or eighth order for apical dendrites
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| developmental disorder of mental health | DOID:0060037 | J:293568 | ||
