Phenotypes associated with this allele

• Allele Symbol: Piezo2^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6501961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm95.1(CAG-GCaMP6f)Hze/Gt(ROSA)26Sor^+ Piezo2^tm1c(KOMP)Wtsi/Piezo2^tm1c(KOMP)Wtsi	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6294467

Genotype
MGI:6294467

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm95.1(CAG-GCaMP6f)Hze}/Gt(ROSA)26Sor⁺; Piezo2^{tm1c(KOMP)Wtsi}/Piezo2^{tm1c(KOMP)Wtsi}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:266637 )

• in some mice injected with a cre-expressing adenovirus

abnormal touch escape response ( J:266637 )

• elevated touch withdrawal reflexes in mice injected with a cre-expressing adenovirus

• following induced spared nerve injury, mice injected with a cre-expressing adenovirus fail to exhibit detect brush even 1 week after nerve injury unlike control mice

• absence of responses to dynamic touch stimulation of hind paw in mice injected with a cre-expressing adenovirus

abnormal nociception after inflammation ( J:266637 )

• following induction of inflammation induced by complete Freunds adjuvant (CFA) or capsaicin, mice injected with a cre-expressing adenovirus exhibit reduced response to brush, air puff and vibration stimuli compared with control mice

• however, response to pinch stimuli is normal

nervous system

abnormal CNS synaptic transmission ( J:266637 )

• neurons in mice injected with a cre-expressing adenovirus fail to exhibit mechanically activated currents unlike control mice

• however, Adelta and C fiber response to high-threshold mechanical stimuli is normal