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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dhx33em1Yazh
endonuclease-mediated mutation 1, Yandong Zhang
MGI:6502108
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dhx33em1Yazh/Dhx33em1Yazh
Krastm4Tyj/Kras+ 		involves: 129S4/SvJae MGI:6502111
cn2
 		Dhx33em1Yazh/Dhx33+
Krastm4Tyj/Kras+ 		involves: 129S4/SvJae MGI:6502114


Genotype
MGI:6502111
cn1
Allelic
Composition		 Dhx33em1Yazh/Dhx33em1Yazh
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx33em1Yazh mutation (0 available); any Dhx33 mutation (22 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:299900 )
• most mice delivered with an adenovirus expressing cre recombinase through nasal inhalation at 8 weeks of age show normal lungs and do not develop lung tumors, and show only small neoplastic regions, indicating inhibition of tumor development that is seen in single Krastm4Tyj mice

respiratory system
decreased lung tumor incidence ( J:299900 )
• most mice delivered with an adenovirus expressing cre recombinase through nasal inhalation at 8 weeks of age show normal lungs and do not develop lung tumors, and show only small neoplastic regions, indicating inhibition of tumor development that is seen in single Krastm4Tyj mice




Genotype
MGI:6502114
cn2
Allelic
Composition		 Dhx33em1Yazh/Dhx33+
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx33em1Yazh mutation (0 available); any Dhx33 mutation (22 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:299900 )
• 5 of 14 mice delivered with an adenovirus expressing cre recombinase through nasal inhalation at 8 weeks of age develop lung tumors compared to single Krastm4Tyj mice in which all mice develop tumors, indicating reduced tumor development

respiratory system
decreased lung tumor incidence ( J:299900 )
• 5 of 14 mice delivered with an adenovirus expressing cre recombinase through nasal inhalation at 8 weeks of age develop lung tumors compared to single Krastm4Tyj mice in which all mice develop tumors, indicating reduced tumor development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory