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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map9tm1.1Bcgen
targeted mutation 1.1, Biocytogen LLC
MGI:6502641
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Map9tm1.1Bcgen/Map9tm1.1Bcgen
Tg(CDX2-cre/ERT2)752Erf/0 		involves: 129S4/SvJaeSor * C57BL/6J * SJL/J MGI:6502655
cn2
 		Map9tm1.1Bcgen/Map9+
Tg(CDX2-cre/ERT2)752Erf/0 		involves: 129S4/SvJaeSor * C57BL/6J * SJL/J MGI:6502656


Genotype
MGI:6502655
cn1
Allelic
Composition		 Map9tm1.1Bcgen/Map9tm1.1Bcgen
Tg(CDX2-cre/ERT2)752Erf/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.1Bcgen mutation (0 available); any Map9 mutation (27 available)
Tg(CDX2-cre/ERT2)752Erf mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal colon morphology ( J:299895 )
• 22.7% of mice injected with tamoxifen develop colonic dysplasia at 15 months post injection
increased colon tumor incidence ( J:299895 )
• 9.1% of mice develop colon cancer at 15 months post injection with tamoxifen

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls

neoplasm
increased colon tumor incidence ( J:299895 )
• 9.1% of mice develop colon cancer at 15 months post injection with tamoxifen
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls




Genotype
MGI:6502656
cn2
Allelic
Composition		 Map9tm1.1Bcgen/Map9+
Tg(CDX2-cre/ERT2)752Erf/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.1Bcgen mutation (0 available); any Map9 mutation (27 available)
Tg(CDX2-cre/ERT2)752Erf mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal colon morphology ( J:299895 )
• 19% of mice injected with tamoxifen develop colonic dysplasia at 15 months post injection

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls

neoplasm
increased incidence of tumors by chemical induction ( J:299895 )
• mice treated with colonic carcinogen azoxymethane (AOM) show higher tumor incidence (100%) compared to treated wild-type mice (67%) and have an increase in tumor number and burden compared with controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory