About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Map9tm1.2Bcgen
targeted mutation 1.2, Biocytogen LLC
MGI:6502642
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Map9tm1.2Bcgen/Map9tm1.2Bcgen involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502657
ht2
 		Map9tm1.2Bcgen/Map9+ involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502658
cx3
 		Map9tm1.2Bcgen/Map9tm1.2Bcgen
Trp53tm1Tyj/Trp53+ 		involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6 MGI:6502662
cx4
 		ApcMin/Apc+
Map9tm1.2Bcgen/Map9tm1.2Bcgen 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J MGI:6502660
cx5
 		ApcMin/Apc+
Map9tm1.2Bcgen/Map9+ 		involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J MGI:6502661


Genotype
MGI:6502657
hm1
Allelic
Composition		 Map9tm1.2Bcgen/Map9tm1.2Bcgen
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:299895 )
• MEFs show an increase in the percentage of cells with detached centrosomes compared with wild-type MEFs
abnormal pericentriolar material morphology ( J:299895 )
• MEFs show an increase in pericentriolar material fragmentation compared with wild-type MEFs
aneuploidy ( J:299895 )
• 70-80% of mouse embryonic fibroblasts (MEFs) are aneuploid
• -the percentage of MEFs with numerical aberrations is almost 3x higher than that of wild-type MEFs
chromosomal instability ( J:299895 )
• MEFs show elevated rates of lagging chromosomes in anaphase indicating increased chromosomal instability

neoplasm
neoplasm ( J:299895 )
N
• mice do not develop visible tumors at 3 months of age




Genotype
MGI:6502658
ht2
Allelic
Composition		 Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal centrosome morphology ( J:299895 )
• MEFs show an increase in the percentage of cells with detached centrosomes compared with wild-type MEFs
abnormal pericentriolar material morphology ( J:299895 )
• MEFs show an increase in pericentriolar material fragmentation compared with wild-type MEFs
aneuploidy ( J:299895 )
• a large percentage of mouse embryonic fibroblasts (MEFs) are aneuploid
chromosomal instability ( J:299895 )
• MEFs show elevated rates of lagging chromosomes in anaphase indicating increased chromosomal instability




Genotype
MGI:6502662
cx3
Allelic
Composition		 Map9tm1.2Bcgen/Map9tm1.2Bcgen
Trp53tm1Tyj/Trp53+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJaeSor * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (27 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
aneuploidy ( J:299895 )
• aneuploidy frequency in splenocytes is higher (58%) compared to single Map9 heterozygotes (39%) or single p53 heterozygotes (23%) or wild-type mice (17%)




Genotype
MGI:6502660
cx4
Allelic
Composition		 ApcMin/Apc+
Map9tm1.2Bcgen/Map9tm1.2Bcgen
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

neoplasm
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 5 of 8 mice showing multiple tumors
• mice have 3-fold more tumors that heterozygous ApcMin heterozygotes, accompanied by significant weight loss
• average tumor burden (sum of all tumor size per mouse) is 2x greater than in ApcMin heterozygotes
• colon tumors harbor chromosomal abnormalities, with tumors having more somatic structural variations, interchromosomal translocations, and intrachromosomal translocations

digestive/alimentary system
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 5 of 8 mice showing multiple tumors
• mice have 3-fold more tumors that heterozygous ApcMin heterozygotes, accompanied by significant weight loss
• average tumor burden (sum of all tumor size per mouse) is 2x greater than in ApcMin heterozygotes
• colon tumors harbor chromosomal abnormalities, with tumors having more somatic structural variations, interchromosomal translocations, and intrachromosomal translocations




Genotype
MGI:6502661
cx5
Allelic
Composition		 ApcMin/Apc+
Map9tm1.2Bcgen/Map9+
Genetic
Background		 involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Map9tm1.2Bcgen mutation (0 available); any Map9 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors

digestive/alimentary system
increased colon tumor incidence ( J:299895 )
• nearly all mice develop intestinal tumors at 3 months of age, with 2 of 10 mice showing multiple tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory