All Phenotypes Nfatc3<tm1c(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nfatc3^{tm1c(EUCOMM)Hmgu}
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6502862

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^{tm1c(EUCOMM)Hmgu}/Nfatc3^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0	involves: C57BL/6 * C57BL/6N * CBA	MGI:7623788

Allelic Composition	Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^{tm1c(EUCOMM)Hmgu}/Nfatc3^{tm1c(EUCOMM)Hmgu} Tg(Itgax-cre)1-1Reiz/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2^tm1Glm mutation (0 available); any Nfatc2 mutation (53 available)
Nfatc3^{tm1c(EUCOMM)Hmgu} mutation (1 available); any Nfatc3 mutation (71 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased interleukin-2 secretion ( J:346703 )

• significantly reduced BPI induced secretion by bone marrow derived cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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