Phenotypes associated with this allele

• Allele Symbol: Sertad3^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:6502863
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sertad3^em1Bcgen/Sertad3^em1Bcgen	involves: C57BL/6N	MGI:6502867

Genotype
MGI:6502867

hm1

• Allelic Composition: Sertad3^em1Bcgen/Sertad3^em1Bcgen
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:300469 )

• increased Influenza A virus (IAV) vRNA, mRNA and cRNA levels found in cultured fibroblasts after infection with H1N1 influenza A/WSN/33 (WSN) virus

• more severe lung injury and inflammation after intranasal infection with WSN virus

• ~10-fold increase in viral titer in lungs after intranasal infection with WSN virus

• increased weight loss after intranasal infection with WSN virus

• 100% mortality rate after intranasal infection with WSN virus

mortality/aging

mortality/aging ( J:300469 )

N • viable

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:300469 )

• increased Influenza A virus (IAV) vRNA, mRNA and cRNA levels found in cultured fibroblasts after infection with H1N1 influenza A/WSN/33 (WSN) virus

• more severe lung injury and inflammation after intranasal infection with WSN virus

• ~10-fold increase in viral titer in lungs after intranasal infection with WSN virus

• increased weight loss after intranasal infection with WSN virus

• 100% mortality rate after intranasal infection with WSN virus

growth/size/body

growth/size/body region phenotype ( J:300469 )

N • normal weight