Phenotypes associated with this allele

• Allele Symbol: Larp1^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6505556
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ins1^tm1.1(cre)Thor/Ins1^+ Larp1^tm1c(EUCOMM)Hmgu/Larp1^tm1c(EUCOMM)Hmgu	involves: C57BL/6J * C57BL/6N	MGI:6506683
cn2	Larp1^tm1c(EUCOMM)Hmgu/Larp1^tm1c(EUCOMM)Hmgu Tg(Ins2-cre)23Herr/0	involves: C57BL/6J * C57BL/6N * CBA/J	MGI:6506668

Genotype
MGI:6506683

cn1

• Allelic Composition: Ins1^{tm1.1(cre)Thor}/Ins1⁺; Larp1^{tm1c(EUCOMM)Hmgu}/Larp1^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:300456 )

N • despite an 80% reduction in Larp1 expression by islets, male mice exhibit no difference in glucose tolerance relative to control males

Genotype
MGI:6506668

cn2

• Allelic Composition: Larp1^{tm1c(EUCOMM)Hmgu}/Larp1^{tm1c(EUCOMM)Hmgu}; Tg(Ins2-cre)23Herr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:300456 )

N • mice exhibit normal glucose homeostasis with no differences in body weight, non-fasting and fasting glycemia, non-fasting plasma insulin, and glucose tolerance observed in males at 4, 8 and 14 weeks of age, or in glucose tolerance observed in females at 13-14 weeks of age relative to gender- and age-matched controls

N • aged male mice show normal body weight and glucose tolerance at 44 weeks of age

N • islets isolated from 7-month old male mice show normal glucose-stimulated insulin secretion with no differences in insulin content relative to control values

N • glucose metabolism is relatively normal even after exposure to a high fat diet or a high branched chain amino acid (BCAA) diet for 8 weeks

impaired glucose tolerance ( J:300456 )

• after long-term exposure (16 weeks) to a BCAA diet, mice exhibit slightly impaired glucose tolerance relative to controls; however, no significant differences in plasma insulin levels, non fasting glycemia, beta cell mass or islet morphology are observed