All Phenotypes Cacng2<em1Tern> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cacng2^em1Tern
endonuclease-mediated mutation 1, Terunaga Nakagawa
MGI:6505622

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacng2^em1Tern/Cacng2^em1Tern	C57BL/6J-Cacng2^em1Tern	MGI:6506057
cx2	Cacng2^em1Tern/Cacng2^em1Tern Gsg1l^tm1.2Tern/Gsg1l^tm1.2Tern	C57BL/6J-Cacng2^em1Tern Gsg1l^tm1.2Tern	MGI:6506055

Allelic Composition	Cacng2^em1Tern/Cacng2^em1Tern
Genetic Background	C57BL/6J-Cacng2^em1Tern

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2^em1Tern mutation (0 available); any Cacng2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal miniature excitatory postsynaptic currents ( J:301313 )

• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude and frequency in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

decreased miniature excitatory postsynaptic current amplitude ( J:301313 )

• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

decreased miniature excitatory postsynaptic current frequency ( J:301313 )

• reduced AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) frequency in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

Allelic Composition	Cacng2^em1Tern/Cacng2^em1Tern Gsg1l^tm1.2Tern/Gsg1l^tm1.2Tern
Genetic Background	C57BL/6J-Cacng2^em1Tern Gsg1l^tm1.2Tern

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacng2^em1Tern mutation (0 available); any Cacng2 mutation (26 available)
Gsg1l^tm1.2Tern mutation (0 available); any Gsg1l mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased excitatory postsynaptic current amplitude ( J:301313 )

• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated spontaneous EPSC (sEPSC) amplitude and frequency in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

short excitatory postsynaptic current decay time ( J:301313 )

• reduced miniature EPSC (mEPSC) decay time in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

short excitatory postsynaptic current rise time ( J:301313 )

• reduced miniature EPSC (mEPSC) rise time in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

abnormal miniature excitatory postsynaptic currents ( J:301313 )

• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude and frequency in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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