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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Jamltm1Fnyi
targeted mutation 1, Fan Yi
MGI:6506225
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Jamltm1Fnyi/Jamltm1Fnyi
Tg(NPHS2-cre)295Lbh/0
B6.Cg-Jamltm1Fnyi Tg(NPHS2-cre)295Lbh MGI:6506861
cn2
Jamltm1Fnyi/Jaml+
Leprdb/Leprdb
Tg(NPHS2-cre)295Lbh/0
B6.Cg-Leprdb Jamltm1Fnyi Tg(NPHS2-cre)295Lbh MGI:6506863
cn3
Jamltm1Fnyi/Jamltm1Fnyi
Leprdb/Leprdb
Tg(NPHS2-cre)295Lbh/0
B6.Cg-Leprdb Jamltm1Fnyi Tg(NPHS2-cre)295Lbh MGI:6506864


Genotype
MGI:6506861
cn1
Allelic
Composition
Jamltm1Fnyi/Jamltm1Fnyi
Tg(NPHS2-cre)295Lbh/0
Genetic
Background
B6.Cg-Jamltm1Fnyi Tg(NPHS2-cre)295Lbh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jamltm1Fnyi mutation (0 available); any Jaml mutation (23 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice
• mice treated with streptozocin and fed a high-fat diet to induce diabetes fail to compared with similarly treated mice
• mice treated with adriamycin to induce nephropathy exhibit lower urinary albumin excretion compared with similarly treated wild-type mice
• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice
• mice treated with adriamycin to induce nephropathy exhibit less glomerulosclerosis compared with similarly treated wild-type mice
• in mice treated with streptozocin and fed a high-fat diet
• however, accumulation in the tubules is comparable to similarly treated wild-type mice

homeostasis/metabolism
• mice treated with streptozocin and fed a high-fat diet to induce diabetes fail to compared with similarly treated mice
• mice treated with adriamycin to induce nephropathy exhibit lower urinary albumin excretion compared with similarly treated wild-type mice
• mice treated with streptozocin and fed a high-fat diet to induce diabetes exhibit decreased urine albumin level and less glomerular and podocyte injuries with reduced podocyte loss and apoptosis compared with similarly treated wild-type mice
• mice treated with adriamycin to induce nephropathy exhibit reduced injury (lower urinary albumin excretion and less glomerulosclerosis) compared with similarly treated wild-type mice

cellular
• in mice treated with streptozocin and fed a high-fat diet to induce diabetes to a lesser extent than in wild-type mice




Genotype
MGI:6506863
cn2
Allelic
Composition
Jamltm1Fnyi/Jaml+
Leprdb/Leprdb
Tg(NPHS2-cre)295Lbh/0
Genetic
Background
B6.Cg-Leprdb Jamltm1Fnyi Tg(NPHS2-cre)295Lbh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jamltm1Fnyi mutation (0 available); any Jaml mutation (23 available)
Leprdb mutation (17 available); any Lepr mutation (122 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• intermediate but not as severe as in mice with wild-type Jaml
• podocyte injury that is as severe as in mice with wild-type Jaml
• not as severe as in mice with wild-type Jaml

homeostasis/metabolism
• intermediate but not as severe as in mice with wild-type Jaml




Genotype
MGI:6506864
cn3
Allelic
Composition
Jamltm1Fnyi/Jamltm1Fnyi
Leprdb/Leprdb
Tg(NPHS2-cre)295Lbh/0
Genetic
Background
B6.Cg-Leprdb Jamltm1Fnyi Tg(NPHS2-cre)295Lbh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jamltm1Fnyi mutation (0 available); any Jaml mutation (23 available)
Leprdb mutation (17 available); any Lepr mutation (122 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• not as severe as in mice with wild-type Jaml
• podocyte injury that is as severe as in mice with wild-type Jaml
• not as severe as in mice with wild-type Jaml
• not as severe as in mice with wild-type Jaml

homeostasis/metabolism
• not as severe as in mice with wild-type Jaml





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory