All Phenotypes Tuba1a<quas> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tuba1a^quas/Tuba1a^quas	involves: C57BL/6J	MGI:6507153
ht2	Tuba1a^em1Rstot/Tuba1a^quas	involves: C57BL/6J * C57BL/6N	MGI:6507156

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enlarged lateral ventricles ( J:278765 )

• lateral ventriculomegaly

enlarged third ventricle ( J:278765 )

abnormal cerebral cortex morphology ( J:278765 )

• reduced cortical tissue

abnormal neuronal precursor cell number ( J:278765 )

• slight 21.5% increase in TBR2-positive intermediate progenitors at E16.5

abnormal neuron physiology ( J:278765 )

increased neuron apoptosis ( J:278765 )

• at E14.5 and E16.5

abnormal neuronal migration ( J:278765 )

• in an EdU labeling study fewer cells labeled at E13.5 migrated to the upper third of the cortex by E14.5 and there is a corresponding increase in the number of cells in the middle third

• changes are more marker at E16.5, consistent with a decrease in radial migration of cells born at E13.5

decreased neuronal precursor proliferation ( J:278765 )

• by 7.2% at E16.5

increased neuronal precursor proliferation ( J:278765 )

• by 18.9% at E14.5

skeleton

abnormal spine curvature ( J:278765 )

• thoracic curvature

cellular

increased neuron apoptosis ( J:278765 )

• at E14.5 and E16.5

abnormal neuronal migration ( J:278765 )

• in an EdU labeling study fewer cells labeled at E13.5 migrated to the upper third of the cortex by E14.5 and there is a corresponding increase in the number of cells in the middle third

• changes are more marker at E16.5, consistent with a decrease in radial migration of cells born at E13.5

decreased neuronal precursor proliferation ( J:278765 )

• by 7.2% at E16.5

increased neuronal precursor proliferation ( J:278765 )

• by 18.9% at E14.5

Allelic Composition	Tuba1a^em1Rstot/Tuba1a^quas
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tuba1a^em1Rstot mutation (0 available); any Tuba1a mutation (15 available)
Tuba1a^quas mutation (0 available); any Tuba1a mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:278765 )

• present at E17.5 but all are lost by weaning

nervous system

abnormal cortical intermediate zone morphology ( J:278765 )

• reduced

enlarged lateral ventricles ( J:278765 )

• lateral ventriculomegaly

enlarged third ventricle ( J:278765 )

abnormal basal ganglion morphology ( J:278765 )

• hypoplastic

abnormal cerebral cortex morphology ( J:278765 )

• reduced cortical tissue

craniofacial

cleft palate ( J:278765 )

skeleton

abnormal spine curvature ( J:278765 )

• thoracic curvature

growth/size/body

cleft palate ( J:278765 )

digestive/alimentary system

cleft palate ( J:278765 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital nervous system abnormality		DOID:2490		J:278765

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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