nervous system
• lateral ventriculomegaly
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• reduced cortical tissue
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• slight 21.5% increase in TBR2-positive intermediate progenitors at E16.5
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• at E14.5 and E16.5
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• in an EdU labeling study fewer cells labeled at E13.5 migrated to the upper third of the cortex by E14.5 and there is a corresponding increase in the number of cells in the middle third
• changes are more marker at E16.5, consistent with a decrease in radial migration of cells born at E13.5
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• by 7.2% at E16.5
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• by 18.9% at E14.5
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skeleton
• thoracic curvature
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cellular
• at E14.5 and E16.5
|
• in an EdU labeling study fewer cells labeled at E13.5 migrated to the upper third of the cortex by E14.5 and there is a corresponding increase in the number of cells in the middle third
• changes are more marker at E16.5, consistent with a decrease in radial migration of cells born at E13.5
|
• by 7.2% at E16.5
|
• by 18.9% at E14.5
|