Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Alb-PCSK9)Mby}
• Allele Name: targeted mutation 1.1, Mohammad Bohlooly-Y
• Allele ID: MGI:6506458
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gt(ROSA)26Sor^tm1.1(Alb-PCSK9)Mby/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6N	MGI:6506468

Genotype
MGI:6506468

ht1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Alb-PCSK9)Mby}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:280156 )

• plasma levels of total cholesterol are increased at 10 and 28 weeks of age, indicating hypercholesterolemia that worsens with age

• mice treated with evolocumab, a monoclonal antibody that inhibits human PCSK9, show reduced plasma cholesterol levels

increased circulating LDL cholesterol level ( J:280156 )

• plasma levels of LDL cholesterol are increased at 10 and 28 weeks of age

growth/size/body

growth/size/body region phenotype ( J:280156 )

N • body weight is normal at 28 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial hypercholesterolemia		DOID:13810	OMIM:143890	J:280156