Phenotypes associated with this allele

• Allele Symbol: Slc9a5^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6507719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc9a5^tm1Smoc/Slc9a5^tm1Smoc	involves: C57BL/6	MGI:6508527

Genotype
MGI:6508527

hm1

• Allelic Composition: Slc9a5^tm1Smoc/Slc9a5^tm1Smoc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:302075 )

♂N • adult male mice show no significant differences in general motor activity and anxiety-like behaviors relative to wild-type controls

abnormal object recognition memory ( J:302075 )

♂ • in a novel object recognition task, males show normal baseline exploratory behavior when presented with two identical objects but spend a significantly longer time than wild-type controls exploring a novel object at 4 and 24 hours after training, suggesting enhanced recognition memory

abnormal spatial reference memory ( J:302075 )

♂ • in a Morris water maze task, males exhibit an enhanced initial learning rate and shortened escape latencies during reversal learning when the platform is removed from target to the opposite quadrant; importantly, males spend a significantly longer time than wild-type controls in the new target quadrant after reversal training

enhanced learning ( J:302075 )

♂ • at 10-12-weeks of age, males show enhanced learning memory in the Morris water maze, novel object recognition, and passive avoidance tasks relative to age- and weight-matched wild-type controls

enhanced passive avoidance behavior ( J:302075 )

♂ • in a passive avoidance task, males show a significantly higher latency to step into the dark compartment on day 3 (24 hours after foot-shock training) relative to wild-type controls

nervous system

abnormal synapse morphology ( J:302075 )

♂ • mice exhibit significantly higher expression levels of synaptophysin (a pre-synaptic component marker) and post-synaptic density 95 (PSD95, a post-synaptic component marker) in hippocampal CA1 and CA3 regions, suggesting alterations in synapse morphology and function

♂ • however, brain morphology is normal

abnormal nervous system physiology ( J:302075 )

♂ • whole brain lysates show upregulated mRNA and protein expression levels of Bdnf and enhanced Bdnf/TrkB signaling