Phenotypes associated with this allele

• Allele Symbol: Dsg2^tm3.1Leu
• Allele Name: targeted mutation 3.1, Rudolf E Leube
• Allele ID: MGI:6508032
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dsg2^tm3.1Leu/Dsg2^tm3.1Leu Tg(Vil1-cre)20Syr/0	involves: 129S7/SvEvBrd * C57BL/6 * DBA/2	MGI:6693360

Genotype
MGI:6693360

cn1

• Allelic Composition: Dsg2^tm3.1Leu/Dsg2^tm3.1Leu; Tg(Vil1-cre)20Syr/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:302333 )

N • normal colon length and intestinal histology

N • no diarrhea

N • normal intestinal basal cell proliferation

N • no intestinal inflammation

N • normal desmosomal plaques in intestines

abnormal intestinal epithelium morphology ( J:302333 )

• wider intercellular spaces between desmosomal plaques in small and large intestine

• normal desmosomal plaques in intestines

increased susceptibility to induced colitis ( J:302333 )

• stronger inflammatory reaction, hyperproliferation and increased epithelial detachment and crypt elongation in intestines and higher fecal bacterial colony forming unit (CFU) count after Citrobacter rodentium exposure

• normal infection clearance after Citrobacter rodentium exposure

increased susceptibility to colitis induced morbidity/mortality ( J:302333 )

• shorter colon, more profound weight loss, intestinal lesions and bloody diarrhea after administration of low doses of dextran sodium sulfate (DSS)

• epithelial loss, edema, inflammatory reactions and goblet cell loss in intestines after administration of low doses of dextran sodium sulfate (DSS)

immune system

increased susceptibility to induced colitis ( J:302333 )

• stronger inflammatory reaction, hyperproliferation and increased epithelial detachment and crypt elongation in intestines and higher fecal bacterial colony forming unit (CFU) count after Citrobacter rodentium exposure

• normal infection clearance after Citrobacter rodentium exposure

increased susceptibility to colitis induced morbidity/mortality ( J:302333 )

• shorter colon, more profound weight loss, intestinal lesions and bloody diarrhea after administration of low doses of dextran sodium sulfate (DSS)

• epithelial loss, edema, inflammatory reactions and goblet cell loss in intestines after administration of low doses of dextran sodium sulfate (DSS)

growth/size/body

growth/size/body region phenotype ( J:302333 )

N • normal postnatal weight gain and colon length

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:302333 )

• shorter colon, more profound weight loss, intestinal lesions and bloody diarrhea after administration of low doses of dextran sodium sulfate (DSS)

• epithelial loss, edema, inflammatory reactions and goblet cell loss in intestines after administration of low doses of dextran sodium sulfate (DSS)