Phenotypes associated with this allele

• Allele Symbol: Cbarp^em1Dsb
• Allele Name: endonuclease-mediated mutation 1, David S Bredt
• Allele ID: MGI:6508393
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cbarp^em1Dsb/Cbarp^em1Dsb	involves: C57BL/6	MGI:6513137

Genotype
MGI:6513137

hm1

• Allelic Composition: Cbarp^em1Dsb/Cbarp^em1Dsb
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal striatum morphology ( J:288382 )

• autoradiography of coronal brain sections revealed a reduction of [125I]alpha-conotoxin MII binding sites that correspond to alpha6-containing nicotinic acetylcholine (nACh) receptors in the striatum

• in contrast, levels of [125I]RTI-55 binding to the striatal dopamine transporter are normal

abnormal synaptic dopamine release ( J:288382 )

• whereas transient nicotine-evoked [3H]dopamine release during the first minute of exposure to 1 uM nicotine is normal, striatal synaptosomes show significant reductions in persistent [3H]dopamine release after treatment with 1 uM or 30 nM nicotine