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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nlrc4em2Vnce
endonuclease-mediated mutation 2, Russell Vance
MGI:6508702
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nlrc4em2Vnce/Nlrc4em2Vnce C57BL/6-Nlrc4em2Vnce MGI:6509149
cx2
 		Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce
Nlrc4em2Vnce/Nlrc4em2Vnce 		involves: C57BL/6 MGI:6509156
cx3
 		Nlrc4em2Vnce/Nlrc4em2Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd 		involves: C57BL/6J * C57BL/6N MGI:6509152


Genotype
MGI:6509149
hm1
Allelic
Composition		 Nlrc4em2Vnce/Nlrc4em2Vnce
Genetic
Background		 C57BL/6-Nlrc4em2Vnce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em2Vnce mutation (1 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• 50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin
• normal level of LDH released by BMDMs exposed to high doses of cytosolic L. pneumophila flagellin

immune system
decreased inflammatory response ( J:294930 )
• severely reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin or to Salmonella Typhimurium
• normal inflammatory response to systemic injection with L. pneumophila flagellin

mortality/aging
mortality/aging ( J:294930 )
N
• viable

reproductive system




Genotype
MGI:6509156
cx2
Allelic
Composition		 Del(13Naip1-Naip5)1Vnce/Del(13Naip1-Naip5)1Vnce
Nlrc4em2Vnce/Nlrc4em2Vnce
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(13Naip1-Naip5)1Vnce mutation (2 available); any Del(13Naip1-Naip5)1Vnce mutation (1 available)
Nlrc4em2Vnce mutation (1 available); any Nlrc4 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• severe reduction in LDH released by bone marrow derived macrophages exposed to Salmonella Typhimurium

immune system
decreased inflammatory response ( J:294930 )
• severe reduction in inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




Genotype
MGI:6509152
cx3
Allelic
Composition		 Nlrc4em2Vnce/Nlrc4em2Vnce
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4em2Vnce mutation (1 available); any Nlrc4 mutation (69 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased lactate dehydrogenase level ( J:294930 )
• 40-50% reduction in LDH released by bone marrow derived macrophages (BMDMs) exposed to low doses of cytosolic Legionella pneumophila flagellin whether primed with LPS or not

immune system
decreased inflammatory response ( J:294930 )
• significantly reduced inflammatory response by bone marrow derived macrophages exposed to cytosolic Legionella pneumophila flagellin whether primed with LPS or not
• severely reduced inflammatory response by bone marrow derived macrophages exposed to Salmonella Typhimurium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory